Cargando…
Genetic effects of polymorphisms in candidate genes and the QTL region on chicken age at first egg
BACKGROUND: The age at first egg (AFE), an important indicator for sexual maturation in female chickens, is controlled by polygenes. Based on our knowledge of reproductive physiology, 6 genes including gonadotrophin releasing hormone-I (GnRH-I), neuropeptide Y (NPY), dopamine D2 receptor (DRD2), vas...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096585/ https://www.ncbi.nlm.nih.gov/pubmed/21492484 http://dx.doi.org/10.1186/1471-2156-12-33 |
_version_ | 1782203728891215872 |
---|---|
author | Xu, Haiping Zeng, Hua Luo, Chenglong Zhang, Dexiang Wang, Qian Sun, Liang Yang, Lishan Zhou, Min Nie, Qinghua Zhang, Xiquan |
author_facet | Xu, Haiping Zeng, Hua Luo, Chenglong Zhang, Dexiang Wang, Qian Sun, Liang Yang, Lishan Zhou, Min Nie, Qinghua Zhang, Xiquan |
author_sort | Xu, Haiping |
collection | PubMed |
description | BACKGROUND: The age at first egg (AFE), an important indicator for sexual maturation in female chickens, is controlled by polygenes. Based on our knowledge of reproductive physiology, 6 genes including gonadotrophin releasing hormone-I (GnRH-I), neuropeptide Y (NPY), dopamine D2 receptor (DRD2), vasoactive intestinal polypeptide (VIP), VIP receptor-1 (VIPR-1), and prolactin (PRL), were selected as candidates for influencing AFE. Additionally, the region between ADL0201 and MCW0241 of chromosome Z was chosen as the candidate QTL region according to some QTL databases. The objective of the present study was to investigate the effects of mutations in candidate genes and the QTL region on chicken AFE. RESULTS: Marker-trait association analysis of 8 mutations in those 6 genes in a Chinese native population found a highly significant association (P < 0.01) between G840327C of the GnRH-I gene with AFE, and it remained significant even with Bonferroni correction. Based on the results of the 2-tailed χ(2 )test, mutations T32742394C, T32742468C, G32742603A, and C33379782T in the candidate QTL region of chromosome Z were selected for marker-trait association analysis. The haplotypes of T32742394C and T32742468C were significantly associated (P < 0.05) with AFE. Bioinformatics analysis indicated that T32742394C and T32742468C were located in the intron region of the SH3-domain GRB2-like 2 (SH3GL2) gene, which appeared to be associated in the endocytosis and development of the oocyte. CONCLUSION: This study found that G840327C of the GnRH-I gene and the haplotypes of T32742394C-T32742468C of the SH3GL2 gene were associated with the chicken AFE. |
format | Text |
id | pubmed-3096585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-30965852011-05-18 Genetic effects of polymorphisms in candidate genes and the QTL region on chicken age at first egg Xu, Haiping Zeng, Hua Luo, Chenglong Zhang, Dexiang Wang, Qian Sun, Liang Yang, Lishan Zhou, Min Nie, Qinghua Zhang, Xiquan BMC Genet Research Article BACKGROUND: The age at first egg (AFE), an important indicator for sexual maturation in female chickens, is controlled by polygenes. Based on our knowledge of reproductive physiology, 6 genes including gonadotrophin releasing hormone-I (GnRH-I), neuropeptide Y (NPY), dopamine D2 receptor (DRD2), vasoactive intestinal polypeptide (VIP), VIP receptor-1 (VIPR-1), and prolactin (PRL), were selected as candidates for influencing AFE. Additionally, the region between ADL0201 and MCW0241 of chromosome Z was chosen as the candidate QTL region according to some QTL databases. The objective of the present study was to investigate the effects of mutations in candidate genes and the QTL region on chicken AFE. RESULTS: Marker-trait association analysis of 8 mutations in those 6 genes in a Chinese native population found a highly significant association (P < 0.01) between G840327C of the GnRH-I gene with AFE, and it remained significant even with Bonferroni correction. Based on the results of the 2-tailed χ(2 )test, mutations T32742394C, T32742468C, G32742603A, and C33379782T in the candidate QTL region of chromosome Z were selected for marker-trait association analysis. The haplotypes of T32742394C and T32742468C were significantly associated (P < 0.05) with AFE. Bioinformatics analysis indicated that T32742394C and T32742468C were located in the intron region of the SH3-domain GRB2-like 2 (SH3GL2) gene, which appeared to be associated in the endocytosis and development of the oocyte. CONCLUSION: This study found that G840327C of the GnRH-I gene and the haplotypes of T32742394C-T32742468C of the SH3GL2 gene were associated with the chicken AFE. BioMed Central 2011-04-15 /pmc/articles/PMC3096585/ /pubmed/21492484 http://dx.doi.org/10.1186/1471-2156-12-33 Text en Copyright ©2011 Xu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Xu, Haiping Zeng, Hua Luo, Chenglong Zhang, Dexiang Wang, Qian Sun, Liang Yang, Lishan Zhou, Min Nie, Qinghua Zhang, Xiquan Genetic effects of polymorphisms in candidate genes and the QTL region on chicken age at first egg |
title | Genetic effects of polymorphisms in candidate genes and the QTL region on chicken age at first egg |
title_full | Genetic effects of polymorphisms in candidate genes and the QTL region on chicken age at first egg |
title_fullStr | Genetic effects of polymorphisms in candidate genes and the QTL region on chicken age at first egg |
title_full_unstemmed | Genetic effects of polymorphisms in candidate genes and the QTL region on chicken age at first egg |
title_short | Genetic effects of polymorphisms in candidate genes and the QTL region on chicken age at first egg |
title_sort | genetic effects of polymorphisms in candidate genes and the qtl region on chicken age at first egg |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096585/ https://www.ncbi.nlm.nih.gov/pubmed/21492484 http://dx.doi.org/10.1186/1471-2156-12-33 |
work_keys_str_mv | AT xuhaiping geneticeffectsofpolymorphismsincandidategenesandtheqtlregiononchickenageatfirstegg AT zenghua geneticeffectsofpolymorphismsincandidategenesandtheqtlregiononchickenageatfirstegg AT luochenglong geneticeffectsofpolymorphismsincandidategenesandtheqtlregiononchickenageatfirstegg AT zhangdexiang geneticeffectsofpolymorphismsincandidategenesandtheqtlregiononchickenageatfirstegg AT wangqian geneticeffectsofpolymorphismsincandidategenesandtheqtlregiononchickenageatfirstegg AT sunliang geneticeffectsofpolymorphismsincandidategenesandtheqtlregiononchickenageatfirstegg AT yanglishan geneticeffectsofpolymorphismsincandidategenesandtheqtlregiononchickenageatfirstegg AT zhoumin geneticeffectsofpolymorphismsincandidategenesandtheqtlregiononchickenageatfirstegg AT nieqinghua geneticeffectsofpolymorphismsincandidategenesandtheqtlregiononchickenageatfirstegg AT zhangxiquan geneticeffectsofpolymorphismsincandidategenesandtheqtlregiononchickenageatfirstegg |