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Caspase Inhibition Blocks Cell Death and Enhances Mitophagy but Fails to Promote T-Cell Lymphoma

Caspase-9 is a component of the apoptosome that mediates cell death following release of cytochrome c from mitochondria. Inhibition of Caspase-9 with a dominant negative construct (Casp9DN) blocks apoptosome function, promotes viability and has been implicated in carcinogenesis. Inhibition of the ap...

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Detalles Bibliográficos
Autores principales:	Wang, Sih-han, Martin, Sean M., Harris, Peter S., Knudson, C. Michael
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096637/ https://www.ncbi.nlm.nih.gov/pubmed/21611191 http://dx.doi.org/10.1371/journal.pone.0019786

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