An Active Site Aromatic Triad in Escherichia coli DNA Pol IV Coordinates Cell Survival and Mutagenesis in Different DNA Damaging Agents

DinB (DNA Pol IV) is a translesion (TLS) DNA polymerase, which inserts a nucleotide opposite an otherwise replication-stalling N(2)-dG lesion in vitro, and confers resistance to nitrofurazone (NFZ), a compound that forms these lesions in vivo. DinB is also known to be part of the cellular response t...

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Detalles Bibliográficos
Autores principales: Benson, Ryan W., Norton, Matthew D., Lin, Ida, Du Comb, William S., Godoy, Veronica G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096655/
https://www.ncbi.nlm.nih.gov/pubmed/21614131
http://dx.doi.org/10.1371/journal.pone.0019944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096655/
https://www.ncbi.nlm.nih.gov/pubmed/21614131
http://dx.doi.org/10.1371/journal.pone.0019944

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