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An Active Site Aromatic Triad in Escherichia coli DNA Pol IV Coordinates Cell Survival and Mutagenesis in Different DNA Damaging Agents
DinB (DNA Pol IV) is a translesion (TLS) DNA polymerase, which inserts a nucleotide opposite an otherwise replication-stalling N(2)-dG lesion in vitro, and confers resistance to nitrofurazone (NFZ), a compound that forms these lesions in vivo. DinB is also known to be part of the cellular response t...
Autores principales: | Benson, Ryan W., Norton, Matthew D., Lin, Ida, Du Comb, William S., Godoy, Veronica G. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096655/ https://www.ncbi.nlm.nih.gov/pubmed/21614131 http://dx.doi.org/10.1371/journal.pone.0019944 |
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