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β(2)-Agonist Induced cAMP Is Decreased in Asthmatic Airway Smooth Muscle Due to Increased PDE4D

BACKGROUND AND OBJECTIVE: Asthma is associated with airway narrowing in response to bronchoconstricting stimuli and increased airway smooth muscle (ASM) mass. In addition, some studies have suggested impaired β-agonist induced ASM relaxation in asthmatics, but the mechanism is not known. OBJECTIVE:...

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Detalles Bibliográficos
Autores principales:	Trian, Thomas, Burgess, Janette K., Niimi, Kyoko, Moir, Lyn M., Ge, Qi, Berger, Patrick, Liggett, Stephen B., Black, Judith L., Oliver, Brian G.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096656/ https://www.ncbi.nlm.nih.gov/pubmed/21611147 http://dx.doi.org/10.1371/journal.pone.0020000

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