Cargando…

The alkylphospholipid, perifosine, radiosensitizes prostate cancer cells both in vitro and in vivo

BACKGROUND: Perifosine is a membrane-targeted alkylphospholipid developed to inhibit the PI3K/Akt pathway and has been suggested as a favorable candidate for combined use with radiotherapy. In this study, we investigated the effect of the combined treatment of perifosine and radiation (CTPR) on pros...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Yuanhong, Ishiyama, Hiromichi, Sun, Mianen, Brinkman, Kathryn L, Wang, Xiaozhen, Zhu, Julie, Mai, Weiyuan, Huang, Ying, Floryk, Daniel, Ittmann, Michael, Thompson, Timothy C, Butler, E Brian, Xu, Bo, Teh, Bin S
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096921/ https://www.ncbi.nlm.nih.gov/pubmed/21496273 http://dx.doi.org/10.1186/1748-717X-6-39

Ejemplares similares

Perifosine, a Bioavailable Alkylphospholipid Akt Inhibitor, Exhibits Antitumor Activity in Murine Models of Cancer Brain Metastasis Through Favorable Tumor Exposure
por: Taniguchi, Keisuke, et al.
Publicado: (2021)

Long-term outcome of a moderately hypofractionated, intensity-modulated radiotherapy approach using an endorectal balloon for patients with localized prostate cancer
por: Teh, Bin S., et al.
Publicado: (2018)

Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids
por: Jiménez-López, José M, et al.
Publicado: (2010)

In Vitro and In Vivo Anti-Schistosomal Activity of the Alkylphospholipid Analog Edelfosine
por: Yepes, Edward, et al.
Publicado: (2014)

Endoplasmic reticulum targeting in Ewing's sarcoma by the alkylphospholipid analog edelfosine
por: Bonilla, Ximena, et al.
Publicado: (2015)

Correction: In Vitro and In Vivo Anti-Schistosomal Activity of the Alkylphospholipid Analog Edelfosine
Publicado: (2015)

Genome-wide identification of genetic determinants for the cytotoxicity of perifosine
por: Zhang, Wei, et al.
Publicado: (2008)

Perifosine as a potential novel anti-telomerase therapy
por: Holohan, Brody, et al.
Publicado: (2015)

Dual Gene Delivery Reagents From Antiproliferative Alkylphospholipids for Combined Antitumor Therapy
por: Gaillard, Boris, et al.
Publicado: (2020)

In Vitro Study of Cytotoxic Mechanisms of Alkylphospholipids and Alkyltriazoles in Acute Lymphoblastic Leukemia Models
por: Jesus, Larissa de Oliveira Passos, et al.
Publicado: (2022)

Emerging treatment options for the treatment of neuroblastoma: potential role of perifosine
por: Sun, Weili, et al.
Publicado: (2012)

Phase I clinical trial of temsirolimus and perifosine for recurrent glioblastoma
por: Kaley, Thomas J., et al.
Publicado: (2020)

Synergistic cytotoxicity of perifosine and ABT‐737 to colon cancer cells
por: Adamová, Barbora, et al.
Publicado: (2022)

Proteome and Acetylome Analysis Identifies Novel Pathways and Targets Regulated by Perifosine in Neuroblastoma
por: Gu, Xiao, et al.
Publicado: (2017)

Inhibition of Glutathione and Thioredoxin Metabolism Enhances Sensitivity to Perifosine in Head and Neck Cancer Cells
por: Simons, Andrean L., et al.
Publicado: (2009)

Lactic Acidosis Interferes With Toxicity of Perifosine to Colorectal Cancer Spheroids: Multimodal Imaging Analysis
por: Pavlatovská, Barbora, et al.
Publicado: (2020)

Mitochondrial Targeting Involving Cholesterol-Rich Lipid Rafts in the Mechanism of Action of the Antitumor Ether Lipid and Alkylphospholipid Analog Edelfosine
por: Mollinedo, Faustino, et al.
Publicado: (2021)

Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine
por: Gills, J J, et al.
Publicado: (2012)

Direct Endoplasmic Reticulum Targeting by the Selective Alkylphospholipid Analog and Antitumor Ether Lipid Edelfosine as a Therapeutic Approach in Pancreatic Cancer
por: Mollinedo, Faustino, et al.
Publicado: (2021)

Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition
por: Gajate, Consuelo, et al.
Publicado: (2021)

Influence of cancerostatic perifosine on membrane fluidity of liposomes and different cell lines as measured by electron paramagnetic resonance
por: Podlipec, Rok, et al.
Publicado: (2012)

A phase I study of single-agent perifosine for recurrent or refractory pediatric CNS and solid tumors
por: Becher, Oren J., et al.
Publicado: (2017)

Perifosine and vitamin D combination induces apoptotic and non-apoptotic cell death in endometrial cancer cells
por: Karagul, Meryem Ilkay, et al.
Publicado: (2020)

Targeting the PI3K/Akt Cell Survival Pathway to Induce Cell Death of HIV-1 Infected Macrophages with Alkylphospholipid Compounds
por: Lucas, Amanda, et al.
Publicado: (2010)

Radiosensitization Effect of Gold Nanoparticles on Plasmid DNA Damage Induced by Therapeutic MV X-rays
por: Yogo, Katsunori, et al.
Publicado: (2022)

Effect of Gold Nanoparticle Radiosensitization on Plasmid DNA Damage Induced by High-Dose-Rate Brachytherapy
por: Yogo, Katsunori, et al.
Publicado: (2021)

Perifosine as a Potential Novel Anti-Cancer Agent Inhibits EGFR/MET-AKT Axis in Malignant Pleural Mesothelioma
por: Pinton, Giulia, et al.
Publicado: (2012)

Radiosensitization in prostate cancer: mechanisms and targets
por: Palacios, Diego A, et al.
Publicado: (2013)

c-Jun NH(2)-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL
por: Fu, Lei, et al.
Publicado: (2010)

Tumor growth and metastasis suppression by Glipr1 gene-modified macrophages in a metastatic prostate cancer model
por: Tabata, K-I, et al.
Publicado: (2011)

Perifosine and CCI 779 Co-Operate to Induce Cell Death and Decrease Proliferation in PTEN-Intact and PTEN-Deficient PDGF-Driven Murine Glioblastoma
por: Pitter, Kenneth L., et al.
Publicado: (2011)

Downregulation of ATXN3 Enhances the Sensitivity to AKT Inhibitors (Perifosine or MK-2206), but Decreases the Sensitivity to Chemotherapeutic Drugs (Etoposide or Cisplatin) in Neuroblastoma Cells
por: Gong, Baocheng, et al.
Publicado: (2021)

Randomized, placebo‐controlled, phase 3 study of perifosine combined with bortezomib and dexamethasone in patients with relapsed, refractory multiple myeloma previously treated with bortezomib
por: Richardson, Paul G., et al.
Publicado: (2020)

Disulfiram Alone Functions as a Radiosensitizer for Pancreatic Cancer Both In Vitro and In Vivo
por: Xu, Ying, et al.
Publicado: (2021)

Correction: Perifosine and CCI 779 Co-Operate to Induce Cell Death and Decrease Proliferation in PTEN-Intact and PTEN-Deficient PDGF-Driven Murine Glioblastoma
por: Pitter, Kenneth L., et al.
Publicado: (2011)

PI3K-Akt Signal Transduction Molecules Maybe Involved in Downregulation of Erythroblasts Apoptosis and Perifosine Increased Its Apoptosis in Chronic Mountain Sickness
por: Zhao, Chengyu, et al.
Publicado: (2017)

Corrigendum: Downregulation of ATXN3 enhances the sensitivity to AKT inhibitors (Perifosine or MK-2206), but decreases the sensitivity to chemotherapeutic drugs (etoposide or cisplatin) in neuroblastoma cells
por: Gong, Baocheng, et al.
Publicado: (2022)

SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt
por: Meng, Haitao, et al.
Publicado: (2013)

A novel UCHL(3) inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair
por: Song, Zhiwang, et al.
Publicado: (2019)

Factors Implicated in Radiation Therapy Failure and Radiosensitization of Prostate Cancer
por: Bonkhoff, Helmut
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_47bin9l36jc7egl0uu5e85gfn7