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The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control

Secondary hyperparathyroidism is a systemic disorder that associates with bone and cardiovascular disease, including arterial calcification. Treatment with calcitriol, the active form of vitamin D, reduces parathyroid hormone levels, but may result in elevations in serum calcium and phosphorus, incr...

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Autores principales: Cozzolino, Mario, Mehmeti, Florjan, Ciceri, Paola, Volpi, Elisa, Stucchi, Andrea, Brenna, Irene, Cusi, Daniele
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096998/
https://www.ncbi.nlm.nih.gov/pubmed/21603158
http://dx.doi.org/10.4061/2011/269060
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author Cozzolino, Mario
Mehmeti, Florjan
Ciceri, Paola
Volpi, Elisa
Stucchi, Andrea
Brenna, Irene
Cusi, Daniele
author_facet Cozzolino, Mario
Mehmeti, Florjan
Ciceri, Paola
Volpi, Elisa
Stucchi, Andrea
Brenna, Irene
Cusi, Daniele
author_sort Cozzolino, Mario
collection PubMed
description Secondary hyperparathyroidism is a systemic disorder that associates with bone and cardiovascular disease, including arterial calcification. Treatment with calcitriol, the active form of vitamin D, reduces parathyroid hormone levels, but may result in elevations in serum calcium and phosphorus, increasing the risk of vascular calcification in dialysis patients. New vitamin D receptor activators (VDRAs) have been developed and investigated with the rationale to treat high serum PTH levels, with a reduced risk of hypercalcemia and hyperphosphatemia. Paricalcitol is a selective VDRA that suppresses PTH secretion with minimal increases on serum calcium and phosphate. Moreover, paricalcitol prevents vascular calcification in experimental models of renal failure, compared with calcitriol.
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spelling pubmed-30969982011-05-20 The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control Cozzolino, Mario Mehmeti, Florjan Ciceri, Paola Volpi, Elisa Stucchi, Andrea Brenna, Irene Cusi, Daniele Int J Nephrol Review Article Secondary hyperparathyroidism is a systemic disorder that associates with bone and cardiovascular disease, including arterial calcification. Treatment with calcitriol, the active form of vitamin D, reduces parathyroid hormone levels, but may result in elevations in serum calcium and phosphorus, increasing the risk of vascular calcification in dialysis patients. New vitamin D receptor activators (VDRAs) have been developed and investigated with the rationale to treat high serum PTH levels, with a reduced risk of hypercalcemia and hyperphosphatemia. Paricalcitol is a selective VDRA that suppresses PTH secretion with minimal increases on serum calcium and phosphate. Moreover, paricalcitol prevents vascular calcification in experimental models of renal failure, compared with calcitriol. SAGE-Hindawi Access to Research 2011-03-29 /pmc/articles/PMC3096998/ /pubmed/21603158 http://dx.doi.org/10.4061/2011/269060 Text en Copyright © 2011 Mario Cozzolino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cozzolino, Mario
Mehmeti, Florjan
Ciceri, Paola
Volpi, Elisa
Stucchi, Andrea
Brenna, Irene
Cusi, Daniele
The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control
title The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control
title_full The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control
title_fullStr The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control
title_full_unstemmed The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control
title_short The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control
title_sort effect of paricalcitol on vascular calcification and cardiovascular disease in uremia: beyond pth control
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096998/
https://www.ncbi.nlm.nih.gov/pubmed/21603158
http://dx.doi.org/10.4061/2011/269060
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