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The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control
Secondary hyperparathyroidism is a systemic disorder that associates with bone and cardiovascular disease, including arterial calcification. Treatment with calcitriol, the active form of vitamin D, reduces parathyroid hormone levels, but may result in elevations in serum calcium and phosphorus, incr...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096998/ https://www.ncbi.nlm.nih.gov/pubmed/21603158 http://dx.doi.org/10.4061/2011/269060 |
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author | Cozzolino, Mario Mehmeti, Florjan Ciceri, Paola Volpi, Elisa Stucchi, Andrea Brenna, Irene Cusi, Daniele |
author_facet | Cozzolino, Mario Mehmeti, Florjan Ciceri, Paola Volpi, Elisa Stucchi, Andrea Brenna, Irene Cusi, Daniele |
author_sort | Cozzolino, Mario |
collection | PubMed |
description | Secondary hyperparathyroidism is a systemic disorder that associates with bone and cardiovascular disease, including arterial calcification. Treatment with calcitriol, the active form of vitamin D, reduces parathyroid hormone levels, but may result in elevations in serum calcium and phosphorus, increasing the risk of vascular calcification in dialysis patients. New vitamin D receptor activators (VDRAs) have been developed and investigated with the rationale to treat high serum PTH levels, with a reduced risk of hypercalcemia and hyperphosphatemia. Paricalcitol is a selective VDRA that suppresses PTH secretion with minimal increases on serum calcium and phosphate. Moreover, paricalcitol prevents vascular calcification in experimental models of renal failure, compared with calcitriol. |
format | Text |
id | pubmed-3096998 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-30969982011-05-20 The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control Cozzolino, Mario Mehmeti, Florjan Ciceri, Paola Volpi, Elisa Stucchi, Andrea Brenna, Irene Cusi, Daniele Int J Nephrol Review Article Secondary hyperparathyroidism is a systemic disorder that associates with bone and cardiovascular disease, including arterial calcification. Treatment with calcitriol, the active form of vitamin D, reduces parathyroid hormone levels, but may result in elevations in serum calcium and phosphorus, increasing the risk of vascular calcification in dialysis patients. New vitamin D receptor activators (VDRAs) have been developed and investigated with the rationale to treat high serum PTH levels, with a reduced risk of hypercalcemia and hyperphosphatemia. Paricalcitol is a selective VDRA that suppresses PTH secretion with minimal increases on serum calcium and phosphate. Moreover, paricalcitol prevents vascular calcification in experimental models of renal failure, compared with calcitriol. SAGE-Hindawi Access to Research 2011-03-29 /pmc/articles/PMC3096998/ /pubmed/21603158 http://dx.doi.org/10.4061/2011/269060 Text en Copyright © 2011 Mario Cozzolino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Cozzolino, Mario Mehmeti, Florjan Ciceri, Paola Volpi, Elisa Stucchi, Andrea Brenna, Irene Cusi, Daniele The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control |
title | The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control |
title_full | The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control |
title_fullStr | The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control |
title_full_unstemmed | The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control |
title_short | The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control |
title_sort | effect of paricalcitol on vascular calcification and cardiovascular disease in uremia: beyond pth control |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096998/ https://www.ncbi.nlm.nih.gov/pubmed/21603158 http://dx.doi.org/10.4061/2011/269060 |
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