Exploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activity

BACKGROUND: MenH (2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase) is a key enzyme in the biosynthesis of menaquinone, catalyzing an unusual 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate. RESULTS: The crystal structure of Staphyloco...

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Detalles Bibliográficos
Autores principales: Dawson, Alice, Fyfe, Paul K, Gillet, Florian, Hunter, William N
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097144/
https://www.ncbi.nlm.nih.gov/pubmed/21513522
http://dx.doi.org/10.1186/1472-6807-11-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097144/
https://www.ncbi.nlm.nih.gov/pubmed/21513522
http://dx.doi.org/10.1186/1472-6807-11-19

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