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Temperature-dependent STIM1 activation induces Ca(2+) influx and modulates gene expression

Intracellular Ca(2+) is essential for diverse cellular functions. Ca(2+) entry into many cell types including immune cells is triggered by depleting endoplasmic reticulum (ER) Ca(2+), a process termed store-operated Ca(2+) entry (SOCE). STIM1 is an ER Ca(2+) sensor. Upon Ca(2+) store depletion, STIM...

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Detalles Bibliográficos
Autores principales: Xiao, Bailong, Coste, Bertrand, Mathur, Jayanti, Patapoutian, Ardem
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097298/
https://www.ncbi.nlm.nih.gov/pubmed/21499266
http://dx.doi.org/10.1038/nchembio.558