Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells

Interferon-induced transmembrane protein 1 (IFITM1) has recently been identified as a new molecular marker in human colorectal cancer. However, its role in glioma carcinogenesis is not known. In this study, we demonstrated that suppression of IFITM1 expression significantly inhibited proliferation o...

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Detalles Bibliográficos
Autores principales: Yu, Fang, Ng, Samuel S. M., Chow, Billy K. C., Sze, Johnny, Lu, Gang, Poon, Wai Sang, Kung, Hsiang-Fu, Lin, Marie C. M.
Formato: Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Laboratory Investigation - Human/Animal Tissue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097340/
https://www.ncbi.nlm.nih.gov/pubmed/20838853
http://dx.doi.org/10.1007/s11060-010-0377-4
Descripción
Sumario:Interferon-induced transmembrane protein 1 (IFITM1) has recently been identified as a new molecular marker in human colorectal cancer. However, its role in glioma carcinogenesis is not known. In this study, we demonstrated that suppression of IFITM1 expression significantly inhibited proliferation of glioma cells in a time-dependent manner. The growth inhibitory effect was mediated by cell cycle arrest. Furthermore, IFITM1 knockdown significantly inhibited migration and invasion of glioma cells, which could be attributed to decreased expression and enzymatic activity of matrix metalloproteinase 9. Taken together, these results suggest that IFITM1 is a potential therapeutic target for gliomas.

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