Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells

Interferon-induced transmembrane protein 1 (IFITM1) has recently been identified as a new molecular marker in human colorectal cancer. However, its role in glioma carcinogenesis is not known. In this study, we demonstrated that suppression of IFITM1 expression significantly inhibited proliferation o...

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Detalles Bibliográficos
Autores principales: Yu, Fang, Ng, Samuel S. M., Chow, Billy K. C., Sze, Johnny, Lu, Gang, Poon, Wai Sang, Kung, Hsiang-Fu, Lin, Marie C. M.
Formato: Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Laboratory Investigation - Human/Animal Tissue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097340/
https://www.ncbi.nlm.nih.gov/pubmed/20838853
http://dx.doi.org/10.1007/s11060-010-0377-4
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author Yu, Fang
Ng, Samuel S. M.
Chow, Billy K. C.
Sze, Johnny
Lu, Gang
Poon, Wai Sang
Kung, Hsiang-Fu
Lin, Marie C. M.
author_facet Yu, Fang
Ng, Samuel S. M.
Chow, Billy K. C.
Sze, Johnny
Lu, Gang
Poon, Wai Sang
Kung, Hsiang-Fu
Lin, Marie C. M.
author_sort Yu, Fang
collection PubMed
description Interferon-induced transmembrane protein 1 (IFITM1) has recently been identified as a new molecular marker in human colorectal cancer. However, its role in glioma carcinogenesis is not known. In this study, we demonstrated that suppression of IFITM1 expression significantly inhibited proliferation of glioma cells in a time-dependent manner. The growth inhibitory effect was mediated by cell cycle arrest. Furthermore, IFITM1 knockdown significantly inhibited migration and invasion of glioma cells, which could be attributed to decreased expression and enzymatic activity of matrix metalloproteinase 9. Taken together, these results suggest that IFITM1 is a potential therapeutic target for gliomas.
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spelling pubmed-30973402011-07-07 Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells Yu, Fang Ng, Samuel S. M. Chow, Billy K. C. Sze, Johnny Lu, Gang Poon, Wai Sang Kung, Hsiang-Fu Lin, Marie C. M. J Neurooncol Laboratory Investigation - Human/Animal Tissue Interferon-induced transmembrane protein 1 (IFITM1) has recently been identified as a new molecular marker in human colorectal cancer. However, its role in glioma carcinogenesis is not known. In this study, we demonstrated that suppression of IFITM1 expression significantly inhibited proliferation of glioma cells in a time-dependent manner. The growth inhibitory effect was mediated by cell cycle arrest. Furthermore, IFITM1 knockdown significantly inhibited migration and invasion of glioma cells, which could be attributed to decreased expression and enzymatic activity of matrix metalloproteinase 9. Taken together, these results suggest that IFITM1 is a potential therapeutic target for gliomas. Springer US 2010-09-14 2011 /pmc/articles/PMC3097340/ /pubmed/20838853 http://dx.doi.org/10.1007/s11060-010-0377-4 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Laboratory Investigation - Human/Animal Tissue
Yu, Fang
Ng, Samuel S. M.
Chow, Billy K. C.
Sze, Johnny
Lu, Gang
Poon, Wai Sang
Kung, Hsiang-Fu
Lin, Marie C. M.
Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells
title Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells
title_full Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells
title_fullStr Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells
title_full_unstemmed Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells
title_short Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells
title_sort knockdown of interferon-induced transmembrane protein 1 (ifitm1) inhibits proliferation, migration, and invasion of glioma cells
topic Laboratory Investigation - Human/Animal Tissue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097340/
https://www.ncbi.nlm.nih.gov/pubmed/20838853
http://dx.doi.org/10.1007/s11060-010-0377-4
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