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The complement system
The complement system consists of a tightly regulated network of proteins that play an important role in host defense and inflammation. Complement activation results in opsonization of pathogens and their removal by phagocytes, as well as cell lysis. Inappropriate complement activation and complemen...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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Springer-Verlag
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097465/ https://www.ncbi.nlm.nih.gov/pubmed/20838815 http://dx.doi.org/10.1007/s00441-010-1034-0 |
| _version_ | 1782203826247303168 |
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| author | Sarma, J. Vidya Ward, Peter A. |
| author_facet | Sarma, J. Vidya Ward, Peter A. |
| author_sort | Sarma, J. Vidya |
| collection | PubMed |
| description | The complement system consists of a tightly regulated network of proteins that play an important role in host defense and inflammation. Complement activation results in opsonization of pathogens and their removal by phagocytes, as well as cell lysis. Inappropriate complement activation and complement deficiencies are the underlying cause of the pathophysiology of many diseases such as systemic lupus erythematosus and asthma. This review represents an overview of the complement system in an effort to understand the beneficial as well as harmful roles it plays during inflammatory responses. |
| format | Text |
| id | pubmed-3097465 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| publisher | Springer-Verlag |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-30974652012-01-01 The complement system Sarma, J. Vidya Ward, Peter A. Cell Tissue Res Review The complement system consists of a tightly regulated network of proteins that play an important role in host defense and inflammation. Complement activation results in opsonization of pathogens and their removal by phagocytes, as well as cell lysis. Inappropriate complement activation and complement deficiencies are the underlying cause of the pathophysiology of many diseases such as systemic lupus erythematosus and asthma. This review represents an overview of the complement system in an effort to understand the beneficial as well as harmful roles it plays during inflammatory responses. Springer-Verlag 2010-09-14 2011 /pmc/articles/PMC3097465/ /pubmed/20838815 http://dx.doi.org/10.1007/s00441-010-1034-0 Text en © Springer-Verlag 2010 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
| spellingShingle | Review Sarma, J. Vidya Ward, Peter A. The complement system |
| title | The complement system |
| title_full | The complement system |
| title_fullStr | The complement system |
| title_full_unstemmed | The complement system |
| title_short | The complement system |
| title_sort | complement system |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097465/ https://www.ncbi.nlm.nih.gov/pubmed/20838815 http://dx.doi.org/10.1007/s00441-010-1034-0 |
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