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Neuroprotective effect of wormwood against lead exposure

BACKGROUND: Lead poisoning is a potential factor in brain damage, neurochemical dysfunction and severe behavioral problems. Considering this effect, our study was carried out to investigate the effects of wormwood to restore enzymes activities, lipid peroxidation and behavioral changes induced by le...

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Autores principales: Kharoubi, O, Slimani, M, Aoues, A
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097587/
https://www.ncbi.nlm.nih.gov/pubmed/21633574
http://dx.doi.org/10.4103/0974-2700.76834
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author Kharoubi, O
Slimani, M
Aoues, A
author_facet Kharoubi, O
Slimani, M
Aoues, A
author_sort Kharoubi, O
collection PubMed
description BACKGROUND: Lead poisoning is a potential factor in brain damage, neurochemical dysfunction and severe behavioral problems. Considering this effect, our study was carried out to investigate the effects of wormwood to restore enzymes activities, lipid peroxidation and behavioral changes induced by lead. METHODS: Thirty Wistar rats were divided into five groups (n = 6 in each group): three groups exposed to 750 ppm of lead acetate in the drinking water for 11 weeks and two groups as control. Aqueous wormwood extract (200 mg/kg body weight) was administrated to intoxicated (Pb(-)+A.AB) and control groups (A.AB) for four supplemental weeks. Activities of acetylcholinesterase (AchE), monoamine oxidase (MAO) and thiobarbituric acid-reactive substances (TBARS) level were determined in the hypothalamus, hippocampus, cortex and striatum of male rats and the grooming and locomotors activity were defined in all groups. RESULTS: The intoxicated group (Pb) has a significantly increased TBARS value compared with the control in all regions (P < 0.05) and, after treatment with the wormwood extract, a significant reduction was noted. The enzyme activity decreased significantly (P < 0.05) in the Pb group compared with the control, essentially for the hippocampus (AchE: -57%, MAO: -41%) and the striatum (AchE: -43%, MAO: -51%). After wormwood extract administration, the AchE and MAO activity were significantly increased in all brain regions compared with the Pb group (P < 0.05). The behavioral test (locomotors and grooming test) indicates a significant hyperactivity in the Pb group compared with the control group. After treatment with wormwood extract, the Pb(-)+A.Ab indicates a lower activity compared with Pb. CONCLUSION: These data suggest that wormwood extract may play a very useful role in reduction of the neurotoxicological damage induced by lead.
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spelling pubmed-30975872011-06-01 Neuroprotective effect of wormwood against lead exposure Kharoubi, O Slimani, M Aoues, A J Emerg Trauma Shock Animal Experimentation BACKGROUND: Lead poisoning is a potential factor in brain damage, neurochemical dysfunction and severe behavioral problems. Considering this effect, our study was carried out to investigate the effects of wormwood to restore enzymes activities, lipid peroxidation and behavioral changes induced by lead. METHODS: Thirty Wistar rats were divided into five groups (n = 6 in each group): three groups exposed to 750 ppm of lead acetate in the drinking water for 11 weeks and two groups as control. Aqueous wormwood extract (200 mg/kg body weight) was administrated to intoxicated (Pb(-)+A.AB) and control groups (A.AB) for four supplemental weeks. Activities of acetylcholinesterase (AchE), monoamine oxidase (MAO) and thiobarbituric acid-reactive substances (TBARS) level were determined in the hypothalamus, hippocampus, cortex and striatum of male rats and the grooming and locomotors activity were defined in all groups. RESULTS: The intoxicated group (Pb) has a significantly increased TBARS value compared with the control in all regions (P < 0.05) and, after treatment with the wormwood extract, a significant reduction was noted. The enzyme activity decreased significantly (P < 0.05) in the Pb group compared with the control, essentially for the hippocampus (AchE: -57%, MAO: -41%) and the striatum (AchE: -43%, MAO: -51%). After wormwood extract administration, the AchE and MAO activity were significantly increased in all brain regions compared with the Pb group (P < 0.05). The behavioral test (locomotors and grooming test) indicates a significant hyperactivity in the Pb group compared with the control group. After treatment with wormwood extract, the Pb(-)+A.Ab indicates a lower activity compared with Pb. CONCLUSION: These data suggest that wormwood extract may play a very useful role in reduction of the neurotoxicological damage induced by lead. Medknow Publications 2011 /pmc/articles/PMC3097587/ /pubmed/21633574 http://dx.doi.org/10.4103/0974-2700.76834 Text en © Journal of Emergencies, Trauma, and Shock http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Animal Experimentation
Kharoubi, O
Slimani, M
Aoues, A
Neuroprotective effect of wormwood against lead exposure
title Neuroprotective effect of wormwood against lead exposure
title_full Neuroprotective effect of wormwood against lead exposure
title_fullStr Neuroprotective effect of wormwood against lead exposure
title_full_unstemmed Neuroprotective effect of wormwood against lead exposure
title_short Neuroprotective effect of wormwood against lead exposure
title_sort neuroprotective effect of wormwood against lead exposure
topic Animal Experimentation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097587/
https://www.ncbi.nlm.nih.gov/pubmed/21633574
http://dx.doi.org/10.4103/0974-2700.76834
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