Leigh syndrome: MRI findings in two children

Leigh syndrome is a progressive neurodegenerative disorder of childhood. The symmetrical necrotic lesions in the basal ganglia and/or brainstem which appear as hyperintense lesions on T2-weighted MRI is characteristic and one of the essential diagnostic criteria. Recognising this MR imaging pattern...

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Detalles Bibliográficos
Autores principales: Kartikasalwah, AL, LH, Ngu
Formato: Texto
Lenguaje:English
Publicado: Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Malaysia 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097793/
https://www.ncbi.nlm.nih.gov/pubmed/21611066
http://dx.doi.org/10.2349/biij.6.1.e6
Descripción
Sumario:Leigh syndrome is a progressive neurodegenerative disorder of childhood. The symmetrical necrotic lesions in the basal ganglia and/or brainstem which appear as hyperintense lesions on T2-weighted MRI is characteristic and one of the essential diagnostic criteria. Recognising this MR imaging pattern in a child with neurological problems should prompt the clinician to investigate for Leigh syndrome. We present here two cases of Leigh syndrome due to different biochemical/genetic defects, and discuss the subtle differences in their MR neuroimaging features.

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