Leigh syndrome: MRI findings in two children

Leigh syndrome is a progressive neurodegenerative disorder of childhood. The symmetrical necrotic lesions in the basal ganglia and/or brainstem which appear as hyperintense lesions on T2-weighted MRI is characteristic and one of the essential diagnostic criteria. Recognising this MR imaging pattern...

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Detalles Bibliográficos
Autores principales: Kartikasalwah, AL, LH, Ngu
Formato: Texto
Lenguaje:English
Publicado: Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Malaysia 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097793/
https://www.ncbi.nlm.nih.gov/pubmed/21611066
http://dx.doi.org/10.2349/biij.6.1.e6
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author Kartikasalwah, AL
LH, Ngu
author_facet Kartikasalwah, AL
LH, Ngu
author_sort Kartikasalwah, AL
collection PubMed
description Leigh syndrome is a progressive neurodegenerative disorder of childhood. The symmetrical necrotic lesions in the basal ganglia and/or brainstem which appear as hyperintense lesions on T2-weighted MRI is characteristic and one of the essential diagnostic criteria. Recognising this MR imaging pattern in a child with neurological problems should prompt the clinician to investigate for Leigh syndrome. We present here two cases of Leigh syndrome due to different biochemical/genetic defects, and discuss the subtle differences in their MR neuroimaging features.
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spelling pubmed-30977932011-05-24 Leigh syndrome: MRI findings in two children Kartikasalwah, AL LH, Ngu Biomed Imaging Interv J Case Report Leigh syndrome is a progressive neurodegenerative disorder of childhood. The symmetrical necrotic lesions in the basal ganglia and/or brainstem which appear as hyperintense lesions on T2-weighted MRI is characteristic and one of the essential diagnostic criteria. Recognising this MR imaging pattern in a child with neurological problems should prompt the clinician to investigate for Leigh syndrome. We present here two cases of Leigh syndrome due to different biochemical/genetic defects, and discuss the subtle differences in their MR neuroimaging features. Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Malaysia 2010-01-01 /pmc/articles/PMC3097793/ /pubmed/21611066 http://dx.doi.org/10.2349/biij.6.1.e6 Text en © 2010 Biomedical Imaging and Intervention Journal http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kartikasalwah, AL
LH, Ngu
Leigh syndrome: MRI findings in two children
title Leigh syndrome: MRI findings in two children
title_full Leigh syndrome: MRI findings in two children
title_fullStr Leigh syndrome: MRI findings in two children
title_full_unstemmed Leigh syndrome: MRI findings in two children
title_short Leigh syndrome: MRI findings in two children
title_sort leigh syndrome: mri findings in two children
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097793/
https://www.ncbi.nlm.nih.gov/pubmed/21611066
http://dx.doi.org/10.2349/biij.6.1.e6
work_keys_str_mv AT kartikasalwahal leighsyndromemrifindingsintwochildren
AT lhngu leighsyndromemrifindingsintwochildren

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