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Chemoprevention of prostate cancer with nutrients and supplements

As the adult population is increasing, prostate cancer (PCa) will become a considerable health problem in the next millennium. This has raised public interest in potential chemoprevention of this disease. As PCa is extremely common and generally slow to progress it is regarded as an ideal candidate...

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Detalles Bibliográficos
Autores principales: Van Poppel, Hendrik, Tombal, Bertrand
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097798/
https://www.ncbi.nlm.nih.gov/pubmed/21629831
http://dx.doi.org/10.2147/CMR.S18503
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author Van Poppel, Hendrik
Tombal, Bertrand
author_facet Van Poppel, Hendrik
Tombal, Bertrand
author_sort Van Poppel, Hendrik
collection PubMed
description As the adult population is increasing, prostate cancer (PCa) will become a considerable health problem in the next millennium. This has raised public interest in potential chemoprevention of this disease. As PCa is extremely common and generally slow to progress it is regarded as an ideal candidate for chemoprevention. At present, the 5 alpha-reductase inhibitors finasteride and dutasteride have been identified as preventive agents. This review describes whether selenium, alpha-tocopherol, isoflavones, lycopene green tea polyphenols, calcium, and resveratrol may be useful for decreasing the risk of PCa in men. Although encouraging results are present, some studies show negative results. Differences in study design, sample size, dose administered, and/or concentrations achieved in the body may be the reason for these inconsistencies. Today, chemopreventive agents may be appropriate for high-risk patients like those with high-grade prostatic intraepithelial neoplasia and other high-risk groups such as patients with elevated prostate specific antigen (PSA) and negative biopsy, rapid PSA velocity, and with a family history of PCa. Although larger randomized controlled studies are needed and epidemiologic evidence should be placed in a clinical context, physicians must be aware of these preventive opportunities in PCa care. Combinations of chemopreventive agents should be carefully investigated because mechanisms of action may be additive or synergistic.
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spelling pubmed-30977982011-05-31 Chemoprevention of prostate cancer with nutrients and supplements Van Poppel, Hendrik Tombal, Bertrand Cancer Manag Res Review As the adult population is increasing, prostate cancer (PCa) will become a considerable health problem in the next millennium. This has raised public interest in potential chemoprevention of this disease. As PCa is extremely common and generally slow to progress it is regarded as an ideal candidate for chemoprevention. At present, the 5 alpha-reductase inhibitors finasteride and dutasteride have been identified as preventive agents. This review describes whether selenium, alpha-tocopherol, isoflavones, lycopene green tea polyphenols, calcium, and resveratrol may be useful for decreasing the risk of PCa in men. Although encouraging results are present, some studies show negative results. Differences in study design, sample size, dose administered, and/or concentrations achieved in the body may be the reason for these inconsistencies. Today, chemopreventive agents may be appropriate for high-risk patients like those with high-grade prostatic intraepithelial neoplasia and other high-risk groups such as patients with elevated prostate specific antigen (PSA) and negative biopsy, rapid PSA velocity, and with a family history of PCa. Although larger randomized controlled studies are needed and epidemiologic evidence should be placed in a clinical context, physicians must be aware of these preventive opportunities in PCa care. Combinations of chemopreventive agents should be carefully investigated because mechanisms of action may be additive or synergistic. Dove Medical Press 2011-04-06 /pmc/articles/PMC3097798/ /pubmed/21629831 http://dx.doi.org/10.2147/CMR.S18503 Text en © 2011 Poppel and Tombal, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Van Poppel, Hendrik
Tombal, Bertrand
Chemoprevention of prostate cancer with nutrients and supplements
title Chemoprevention of prostate cancer with nutrients and supplements
title_full Chemoprevention of prostate cancer with nutrients and supplements
title_fullStr Chemoprevention of prostate cancer with nutrients and supplements
title_full_unstemmed Chemoprevention of prostate cancer with nutrients and supplements
title_short Chemoprevention of prostate cancer with nutrients and supplements
title_sort chemoprevention of prostate cancer with nutrients and supplements
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097798/
https://www.ncbi.nlm.nih.gov/pubmed/21629831
http://dx.doi.org/10.2147/CMR.S18503
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