A novel scoring function for discriminating hyperthermophilic and mesophilic proteins with application to predicting relative thermostability of protein mutants

BACKGROUND: The ability to design thermostable proteins is theoretically important and practically useful. Robust and accurate algorithms, however, remain elusive. One critical problem is the lack of reliable methods to estimate the relative thermostability of possible mutants. RESULTS: We report a...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yunqi, Middaugh, C Russell, Fang, Jianwen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098108/
https://www.ncbi.nlm.nih.gov/pubmed/20109199
http://dx.doi.org/10.1186/1471-2105-11-62

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098108/
https://www.ncbi.nlm.nih.gov/pubmed/20109199
http://dx.doi.org/10.1186/1471-2105-11-62

Ejemplares similares