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Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate

BACKGROUND: The enzyme dihydropteroate synthase (DHPS) participates in the de novo synthesis of folate cofactors by catalyzing the formation of 7,8-dihydropteroate from condensation of p-aminobenzoic acid with 6-hydroxymethyl-7,8-dihydropteroate pyrophosphate. DHPS is absent from humans, who acquire...

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Detalles Bibliográficos
Autores principales:	Morgan, Rachel E, Batot, Gaëlle O, Dement, Jennifer M, Rao, Vincenzo A, Eadsforth, Thomas C, Hunter, William N
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098144/ https://www.ncbi.nlm.nih.gov/pubmed/21554707 http://dx.doi.org/10.1186/1472-6807-11-21

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