A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

Sphingolipids, lipids with a common sphingoid base (also termed long chain base) backbone, play essential cellular structural and signaling functions. Alterations of sphingolipid levels have been implicated in many diseases, including neurodegenerative disorders. However, it remains largely unclear...

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Detalles Bibliográficos
Autores principales: Zhao, Lihong, Spassieva, Stefka D., Jucius, Thomas J., Shultz, Leonard D., Shick, H. Elizabeth, Macklin, Wendy B., Hannun, Yusuf A., Obeid, Lina M., Ackerman, Susan L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098191/
https://www.ncbi.nlm.nih.gov/pubmed/21625621
http://dx.doi.org/10.1371/journal.pgen.1002063

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