Inhibition of Both HIV-1 Reverse Transcription and Gene Expression by a Cyclic Peptide that Binds the Tat-Transactivating Response Element (TAR) RNA

The RNA response element TAR plays a critical role in HIV replication by providing a binding site for the recruitment of the viral transactivator protein Tat. Using a structure-guided approach, we have developed a series of conformationally-constrained cyclic peptides that act as structural mimics o...

Descripción completa

Detalles Bibliográficos
Autores principales: Lalonde, Matthew S., Lobritz, Michael A., Ratcliff, Annette, Chamanian, Mastooreh, Athanassiou, Zafiria, Tyagi, Mudit, Wong, Julian, Robinson, John A., Karn, Jonathan, Varani, Gabriele, Arts, Eric J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098202/
https://www.ncbi.nlm.nih.gov/pubmed/21625572
http://dx.doi.org/10.1371/journal.ppat.1002038

Ejemplares similares

Ejemplares similares