Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

BACKGROUND: Nrf2 is a key transcriptional regulator of a battery of genes that facilitate phase II/III drug metabolism and defence against oxidative stress. Nrf2 is largely regulated by Keap1, which directs Nrf2 for proteasomal degradation. The Nrf2/Keap1 system is dysregulated in lung, head and nec...

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Detalles Bibliográficos
Autores principales: Lister, Adam, Nedjadi, Taoufik, Kitteringham, Neil R, Campbell, Fiona, Costello, Eithne, Lloyd, Bryony, Copple, Ian M, Williams, Samantha, Owen, Andrew, Neoptolemos, John P, Goldring, Chris E, Park, B Kevin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098205/
https://www.ncbi.nlm.nih.gov/pubmed/21489257
http://dx.doi.org/10.1186/1476-4598-10-37

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098205/
https://www.ncbi.nlm.nih.gov/pubmed/21489257
http://dx.doi.org/10.1186/1476-4598-10-37

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