A Multiscale Approach to Characterize the Early Aggregation Steps of the Amyloid-Forming Peptide GNNQQNY from the Yeast Prion Sup-35

The self-organization of peptides into amyloidogenic oligomers is one of the key events for a wide range of molecular and degenerative diseases. Atomic-resolution characterization of the mechanisms responsible for the aggregation process and the resulting structures is thus a necessary step to impro...

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Detalles Bibliográficos
Autores principales: Nasica-Labouze, Jessica, Meli, Massimiliano, Derreumaux, Philippe, Colombo, Giorgio, Mousseau, Normand
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098217/
https://www.ncbi.nlm.nih.gov/pubmed/21625573
http://dx.doi.org/10.1371/journal.pcbi.1002051

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