A Gamma Interferon Independent Mechanism of CD4 T Cell Mediated Control of M. tuberculosis Infection in vivo

CD4 T cell deficiency or defective IFNγ signaling render humans and mice highly susceptible to Mycobacterium tuberculosis (Mtb) infection. The prevailing model is that Th1 CD4 T cells produce IFNγ to activate bactericidal effector mechanisms of infected macrophages. Here we test this model by direct...

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Detalles Bibliográficos
Autores principales: Gallegos, Alena M., van Heijst, Jeroen W. J., Samstein, Miriam, Su, Xiaodi, Pamer, Eric G., Glickman, Michael S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098235/
https://www.ncbi.nlm.nih.gov/pubmed/21625591
http://dx.doi.org/10.1371/journal.ppat.1002052

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