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Mitochondrial Ubiquitin Ligase MARCH5 Promotes TLR7 Signaling by Attenuating TANK Action
The signaling of Toll-like receptors (TLRs) is the host's first line of defense against microbial invasion. The mitochondrion is emerging as a critical platform for antiviral signal transduction. The regulatory role of mitochondria for TLR signaling remains to be explored. Here, we show that th...
Autores principales: | Shi, He-Xin, Liu, Xing, Wang, Qiang, Tang, Pei-Pei, Liu, Xin-Yi, Shan, Yu-Fei, Wang, Chen |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098239/ https://www.ncbi.nlm.nih.gov/pubmed/21625535 http://dx.doi.org/10.1371/journal.ppat.1002057 |
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