TRPC channel modulation in podocytes—inching toward novel treatments for glomerular disease

Glomerular kidney disease is a major healthcare burden and considered to represent a sum of disorders that evade a refined and effective treatment. Excellent biological and genetic studies have defined pathways that go awry in podocytes, which are the regulatory cells of the glomerular filter. The q...

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Detalles Bibliográficos
Autores principales: El Hindi, Shafic, Reiser, Jochen
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Educational Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098353/
https://www.ncbi.nlm.nih.gov/pubmed/21161284
http://dx.doi.org/10.1007/s00467-010-1718-4
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author El Hindi, Shafic
Reiser, Jochen
author_facet El Hindi, Shafic
Reiser, Jochen
author_sort El Hindi, Shafic
collection PubMed
description Glomerular kidney disease is a major healthcare burden and considered to represent a sum of disorders that evade a refined and effective treatment. Excellent biological and genetic studies have defined pathways that go awry in podocytes, which are the regulatory cells of the glomerular filter. The question now is how to define targets for novel improved therapies. In this review, we summarize critical points around targeting the TRPC6 channel in podocytes.
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spelling pubmed-30983532011-07-07 TRPC channel modulation in podocytes—inching toward novel treatments for glomerular disease El Hindi, Shafic Reiser, Jochen Pediatr Nephrol Educational Review Glomerular kidney disease is a major healthcare burden and considered to represent a sum of disorders that evade a refined and effective treatment. Excellent biological and genetic studies have defined pathways that go awry in podocytes, which are the regulatory cells of the glomerular filter. The question now is how to define targets for novel improved therapies. In this review, we summarize critical points around targeting the TRPC6 channel in podocytes. Springer-Verlag 2010-12-16 2011-07 /pmc/articles/PMC3098353/ /pubmed/21161284 http://dx.doi.org/10.1007/s00467-010-1718-4 Text en © IPNA 2010
spellingShingle Educational Review
El Hindi, Shafic
Reiser, Jochen
TRPC channel modulation in podocytes—inching toward novel treatments for glomerular disease
title TRPC channel modulation in podocytes—inching toward novel treatments for glomerular disease
title_full TRPC channel modulation in podocytes—inching toward novel treatments for glomerular disease
title_fullStr TRPC channel modulation in podocytes—inching toward novel treatments for glomerular disease
title_full_unstemmed TRPC channel modulation in podocytes—inching toward novel treatments for glomerular disease
title_short TRPC channel modulation in podocytes—inching toward novel treatments for glomerular disease
title_sort trpc channel modulation in podocytes—inching toward novel treatments for glomerular disease
topic Educational Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098353/
https://www.ncbi.nlm.nih.gov/pubmed/21161284
http://dx.doi.org/10.1007/s00467-010-1718-4
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