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Assessment of long-term renal complications in extremely low birth weight children

We assessed the long-term renal complications in a regional cohort of extremely low birth weight (ELBW) children born in 2002–2004. The study group, comprising 78 children born as ELBW infants (88% of the available cohort), was evaluated with measurement of serum cystatin C, urinary albumin excretio...

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Autores principales: Kwinta, Przemko, Klimek, Małgorzata, Drozdz, Dorota, Grudzień, Andrzej, Jagła, Mateusz, Zasada, Magdalena, Pietrzyk, Jacek Jozef
Formato: Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098355/
https://www.ncbi.nlm.nih.gov/pubmed/21461881
http://dx.doi.org/10.1007/s00467-011-1840-y
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author Kwinta, Przemko
Klimek, Małgorzata
Drozdz, Dorota
Grudzień, Andrzej
Jagła, Mateusz
Zasada, Magdalena
Pietrzyk, Jacek Jozef
author_facet Kwinta, Przemko
Klimek, Małgorzata
Drozdz, Dorota
Grudzień, Andrzej
Jagła, Mateusz
Zasada, Magdalena
Pietrzyk, Jacek Jozef
author_sort Kwinta, Przemko
collection PubMed
description We assessed the long-term renal complications in a regional cohort of extremely low birth weight (ELBW) children born in 2002–2004. The study group, comprising 78 children born as ELBW infants (88% of the available cohort), was evaluated with measurement of serum cystatin C, urinary albumin excretion, renal ultrasound, and 24-h ambulatory blood pressure measurements. The control group included 38 children born full-term selected from one general practice in the district. Study patients were evaluated at a mean age of 6.7 years, and had a median birthweight of 890 g (25th–75th percentile: 760–950 g) and a median gestational age of 27 weeks (25th–75th percentile: 26–29 weeks). Mean serum cystatin C levels were significantly higher (0.64 vs. 0.59 mg/l; p = 0.01) in the ELBW group. Hypertension was diagnosed in 8/78 ELBW and 2/38 of the control children (p = 0.5). Microalbuminuria (>20 mg/g of creatinine) was detected only in five ELBW children (p = 0.17). The mean renal volume was significantly lower in the ELBW group (absolute kidney volume 81 ml vs. 113 ml; p < 0.001, relative kidney volume 85 vs. 97%; p < 0.001). Abnormally small kidneys (<2/3 of predicted size) were detected in 19 ELBW and four control children (p = 0.08). Multivariate logistic regression revealed that the only independent risk factor for renal complications was weight gained during neonatal hospitalization (odds ratio: 0.67; 95% confidence interval: 0.39–0.94). Serum cystatin C and kidney volume are significantly lower in school-age ELBW children. It is important to include systematic renal evaluation in the follow-up programs of ELBW infants.
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spelling pubmed-30983552011-07-07 Assessment of long-term renal complications in extremely low birth weight children Kwinta, Przemko Klimek, Małgorzata Drozdz, Dorota Grudzień, Andrzej Jagła, Mateusz Zasada, Magdalena Pietrzyk, Jacek Jozef Pediatr Nephrol Original Article We assessed the long-term renal complications in a regional cohort of extremely low birth weight (ELBW) children born in 2002–2004. The study group, comprising 78 children born as ELBW infants (88% of the available cohort), was evaluated with measurement of serum cystatin C, urinary albumin excretion, renal ultrasound, and 24-h ambulatory blood pressure measurements. The control group included 38 children born full-term selected from one general practice in the district. Study patients were evaluated at a mean age of 6.7 years, and had a median birthweight of 890 g (25th–75th percentile: 760–950 g) and a median gestational age of 27 weeks (25th–75th percentile: 26–29 weeks). Mean serum cystatin C levels were significantly higher (0.64 vs. 0.59 mg/l; p = 0.01) in the ELBW group. Hypertension was diagnosed in 8/78 ELBW and 2/38 of the control children (p = 0.5). Microalbuminuria (>20 mg/g of creatinine) was detected only in five ELBW children (p = 0.17). The mean renal volume was significantly lower in the ELBW group (absolute kidney volume 81 ml vs. 113 ml; p < 0.001, relative kidney volume 85 vs. 97%; p < 0.001). Abnormally small kidneys (<2/3 of predicted size) were detected in 19 ELBW and four control children (p = 0.08). Multivariate logistic regression revealed that the only independent risk factor for renal complications was weight gained during neonatal hospitalization (odds ratio: 0.67; 95% confidence interval: 0.39–0.94). Serum cystatin C and kidney volume are significantly lower in school-age ELBW children. It is important to include systematic renal evaluation in the follow-up programs of ELBW infants. Springer Berlin Heidelberg 2011-07-01 2011 /pmc/articles/PMC3098355/ /pubmed/21461881 http://dx.doi.org/10.1007/s00467-011-1840-y Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/2.0/Open AccessThis is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/2.0 (https://creativecommons.org/licenses/by-nc/2.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Article
Kwinta, Przemko
Klimek, Małgorzata
Drozdz, Dorota
Grudzień, Andrzej
Jagła, Mateusz
Zasada, Magdalena
Pietrzyk, Jacek Jozef
Assessment of long-term renal complications in extremely low birth weight children
title Assessment of long-term renal complications in extremely low birth weight children
title_full Assessment of long-term renal complications in extremely low birth weight children
title_fullStr Assessment of long-term renal complications in extremely low birth weight children
title_full_unstemmed Assessment of long-term renal complications in extremely low birth weight children
title_short Assessment of long-term renal complications in extremely low birth weight children
title_sort assessment of long-term renal complications in extremely low birth weight children
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098355/
https://www.ncbi.nlm.nih.gov/pubmed/21461881
http://dx.doi.org/10.1007/s00467-011-1840-y
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