Cargando…

A 3D-structural model of unsulfated chondroitin from high-field NMR: 4-sulfation has little effect on backbone conformation

The glycosaminoglycan chondroitin sulfate is essential in human health and disease but exactly how sulfation dictates its 3D-strucutre at the atomic level is unclear. To address this, we have purified homogenous oligosaccharides of unsulfated chondroitin (with and without (15)N-enrichment) and analy...

Descripción completa

Detalles Bibliográficos
Autores principales: Sattelle, Benedict M., Shakeri, Javad, Roberts, Ian S., Almond, Andrew
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098369/
https://www.ncbi.nlm.nih.gov/pubmed/20022001
http://dx.doi.org/10.1016/j.carres.2009.11.013