ParkDB: a Parkinson’s disease gene expression database

Parkinson’s disease (PD) is a common, adult-onset, neuro-degenerative disorder characterized by the degeneration of cardinal motor signs mainly due to the loss of dopaminergic neurons in the substantia nigra. To date, researchers still have limited understanding of the key molecular events that prov...

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Autores principales: Taccioli, Cristian, Tegnér, Jesper, Maselli, Vincenza, Gomez-Cabrero, David, Altobelli, Gioia, Emmett, Warren, Lescai, Francesco, Gustincich, Stefano, Stupka, Elia
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Database Tool
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098727/
https://www.ncbi.nlm.nih.gov/pubmed/21593080
http://dx.doi.org/10.1093/database/bar007
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author Taccioli, Cristian
Tegnér, Jesper
Maselli, Vincenza
Gomez-Cabrero, David
Altobelli, Gioia
Emmett, Warren
Lescai, Francesco
Gustincich, Stefano
Stupka, Elia
author_facet Taccioli, Cristian
Tegnér, Jesper
Maselli, Vincenza
Gomez-Cabrero, David
Altobelli, Gioia
Emmett, Warren
Lescai, Francesco
Gustincich, Stefano
Stupka, Elia
author_sort Taccioli, Cristian
collection PubMed
description Parkinson’s disease (PD) is a common, adult-onset, neuro-degenerative disorder characterized by the degeneration of cardinal motor signs mainly due to the loss of dopaminergic neurons in the substantia nigra. To date, researchers still have limited understanding of the key molecular events that provoke neurodegeneration in this disease. Here, we present ParkDB, the first queryable database dedicated to gene expression in PD. ParkDB contains a complete set of re-analyzed, curated and annotated microarray datasets. This resource enables scientists to identify and compare expression signatures involved in PD and dopaminergic neuron differentiation under different biological conditions and across species. Database URL: http://www2.cancer.ucl.ac.uk/Parkinson_Db2/
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spelling pubmed-30987272011-05-20 ParkDB: a Parkinson’s disease gene expression database Taccioli, Cristian Tegnér, Jesper Maselli, Vincenza Gomez-Cabrero, David Altobelli, Gioia Emmett, Warren Lescai, Francesco Gustincich, Stefano Stupka, Elia Database (Oxford) Database Tool Parkinson’s disease (PD) is a common, adult-onset, neuro-degenerative disorder characterized by the degeneration of cardinal motor signs mainly due to the loss of dopaminergic neurons in the substantia nigra. To date, researchers still have limited understanding of the key molecular events that provoke neurodegeneration in this disease. Here, we present ParkDB, the first queryable database dedicated to gene expression in PD. ParkDB contains a complete set of re-analyzed, curated and annotated microarray datasets. This resource enables scientists to identify and compare expression signatures involved in PD and dopaminergic neuron differentiation under different biological conditions and across species. Database URL: http://www2.cancer.ucl.ac.uk/Parkinson_Db2/ Oxford University Press 2011-05-18 /pmc/articles/PMC3098727/ /pubmed/21593080 http://dx.doi.org/10.1093/database/bar007 Text en © The Author(s) 2011. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/2.5 This is Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Database Tool
Taccioli, Cristian
Tegnér, Jesper
Maselli, Vincenza
Gomez-Cabrero, David
Altobelli, Gioia
Emmett, Warren
Lescai, Francesco
Gustincich, Stefano
Stupka, Elia
ParkDB: a Parkinson’s disease gene expression database
title ParkDB: a Parkinson’s disease gene expression database
title_full ParkDB: a Parkinson’s disease gene expression database
title_fullStr ParkDB: a Parkinson’s disease gene expression database
title_full_unstemmed ParkDB: a Parkinson’s disease gene expression database
title_short ParkDB: a Parkinson’s disease gene expression database
title_sort parkdb: a parkinson’s disease gene expression database
topic Database Tool
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098727/
https://www.ncbi.nlm.nih.gov/pubmed/21593080
http://dx.doi.org/10.1093/database/bar007
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