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Mycobacterial infections in a large Virginia hospital, 2001-2009

BACKGROUND: In areas where both tuberculosis (TB) and nontuberculous mycobacteria (NTM) are prevalent, descriptive studies of the clinical features of individual mycobacteria are needed to inform clinical triage. METHODS: We queried the University of Virginia Clinical Data Repository for all mycobac...

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Autores principales: Satyanarayana, Gowri, Heysell, Scott K, Scully, Kenneth W, Houpt, Eric R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098778/
https://www.ncbi.nlm.nih.gov/pubmed/21545738
http://dx.doi.org/10.1186/1471-2334-11-113
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author Satyanarayana, Gowri
Heysell, Scott K
Scully, Kenneth W
Houpt, Eric R
author_facet Satyanarayana, Gowri
Heysell, Scott K
Scully, Kenneth W
Houpt, Eric R
author_sort Satyanarayana, Gowri
collection PubMed
description BACKGROUND: In areas where both tuberculosis (TB) and nontuberculous mycobacteria (NTM) are prevalent, descriptive studies of the clinical features of individual mycobacteria are needed to inform clinical triage. METHODS: We queried the University of Virginia Clinical Data Repository for all mycobacterial infections from 2001-2009. RESULTS: Of 494 mycobacterial infections in 467 patients there were 22 species. Patients with pulmonary Tb were more likely to be reported as immigrants (p < 0.001) and less likely to have a predisposing risk factor for NTM (pre-existing lung disease or host predisposition; p = 0.002). Review of chest CT scans revealed that TB infection was more likely to exhibit cavities and pleural effusion than NTM infection (p < 0.05). Among NTM infections M. kansasii, M. xenopi, and M. fortuitum were more likely than MAC to have cavities. There were at least 83 patients that met criteria for NTM lung disease and these were caused by 9 species. M. abscessus infection was associated with cystic fibrosis and M. xenopi infection was associated with male gender. CONCLUSIONS: In our center mycobacterial infections were common and of diverse species. Immigrant status, cavities, and effusion were associated with TB vs. NTM.
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spelling pubmed-30987782011-05-21 Mycobacterial infections in a large Virginia hospital, 2001-2009 Satyanarayana, Gowri Heysell, Scott K Scully, Kenneth W Houpt, Eric R BMC Infect Dis Research Article BACKGROUND: In areas where both tuberculosis (TB) and nontuberculous mycobacteria (NTM) are prevalent, descriptive studies of the clinical features of individual mycobacteria are needed to inform clinical triage. METHODS: We queried the University of Virginia Clinical Data Repository for all mycobacterial infections from 2001-2009. RESULTS: Of 494 mycobacterial infections in 467 patients there were 22 species. Patients with pulmonary Tb were more likely to be reported as immigrants (p < 0.001) and less likely to have a predisposing risk factor for NTM (pre-existing lung disease or host predisposition; p = 0.002). Review of chest CT scans revealed that TB infection was more likely to exhibit cavities and pleural effusion than NTM infection (p < 0.05). Among NTM infections M. kansasii, M. xenopi, and M. fortuitum were more likely than MAC to have cavities. There were at least 83 patients that met criteria for NTM lung disease and these were caused by 9 species. M. abscessus infection was associated with cystic fibrosis and M. xenopi infection was associated with male gender. CONCLUSIONS: In our center mycobacterial infections were common and of diverse species. Immigrant status, cavities, and effusion were associated with TB vs. NTM. BioMed Central 2011-05-05 /pmc/articles/PMC3098778/ /pubmed/21545738 http://dx.doi.org/10.1186/1471-2334-11-113 Text en Copyright ©2011 Satyanarayana et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Satyanarayana, Gowri
Heysell, Scott K
Scully, Kenneth W
Houpt, Eric R
Mycobacterial infections in a large Virginia hospital, 2001-2009
title Mycobacterial infections in a large Virginia hospital, 2001-2009
title_full Mycobacterial infections in a large Virginia hospital, 2001-2009
title_fullStr Mycobacterial infections in a large Virginia hospital, 2001-2009
title_full_unstemmed Mycobacterial infections in a large Virginia hospital, 2001-2009
title_short Mycobacterial infections in a large Virginia hospital, 2001-2009
title_sort mycobacterial infections in a large virginia hospital, 2001-2009
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098778/
https://www.ncbi.nlm.nih.gov/pubmed/21545738
http://dx.doi.org/10.1186/1471-2334-11-113
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