The functional role of long non-coding RNA in human carcinomas

Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biological functions of the vast majority...

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Detalles Bibliográficos
Autores principales: Gibb, Ewan A, Brown, Carolyn J, Lam, Wan L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098824/
https://www.ncbi.nlm.nih.gov/pubmed/21489289
http://dx.doi.org/10.1186/1476-4598-10-38
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author Gibb, Ewan A
Brown, Carolyn J
Lam, Wan L
author_facet Gibb, Ewan A
Brown, Carolyn J
Lam, Wan L
author_sort Gibb, Ewan A
collection PubMed
description Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biological functions of the vast majority remain unknown. Recently, evidence has begun to accumulate describing the molecular mechanisms by which these RNA species function, providing insight into the functional roles they may play in tumorigenesis. In this review, we highlight the emerging functional role of lncRNAs in human cancer.
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spelling pubmed-30988242011-05-21 The functional role of long non-coding RNA in human carcinomas Gibb, Ewan A Brown, Carolyn J Lam, Wan L Mol Cancer Review Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biological functions of the vast majority remain unknown. Recently, evidence has begun to accumulate describing the molecular mechanisms by which these RNA species function, providing insight into the functional roles they may play in tumorigenesis. In this review, we highlight the emerging functional role of lncRNAs in human cancer. BioMed Central 2011-04-13 /pmc/articles/PMC3098824/ /pubmed/21489289 http://dx.doi.org/10.1186/1476-4598-10-38 Text en Copyright ©2011 Gibb et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Gibb, Ewan A
Brown, Carolyn J
Lam, Wan L
The functional role of long non-coding RNA in human carcinomas
title The functional role of long non-coding RNA in human carcinomas
title_full The functional role of long non-coding RNA in human carcinomas
title_fullStr The functional role of long non-coding RNA in human carcinomas
title_full_unstemmed The functional role of long non-coding RNA in human carcinomas
title_short The functional role of long non-coding RNA in human carcinomas
title_sort functional role of long non-coding rna in human carcinomas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098824/
https://www.ncbi.nlm.nih.gov/pubmed/21489289
http://dx.doi.org/10.1186/1476-4598-10-38
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