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Genome-Wide Association Study for Atopy and Allergic Rhinitis in a Singapore Chinese Population

Allergic rhinitis (AR) is an atopic disease which affects about 600 million people worldwide and results from a complex interplay between genetic and environmental factors. However genetic association studies on known candidate genes yielded variable results. The aim of this study is to identify the...

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Autores principales: Andiappan, Anand Kumar, Wang, De Yun, Anantharaman, Ramani, Parate, Pallavi Nilkanth, Suri, Bani Kaur, Low, Hui Qi, Li, Yi, Zhao, Wanting, Castagnoli, Paola, Liu, Jianjun, Chew, Fook Tim
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098846/
https://www.ncbi.nlm.nih.gov/pubmed/21625490
http://dx.doi.org/10.1371/journal.pone.0019719
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author Andiappan, Anand Kumar
Wang, De Yun
Anantharaman, Ramani
Parate, Pallavi Nilkanth
Suri, Bani Kaur
Low, Hui Qi
Li, Yi
Zhao, Wanting
Castagnoli, Paola
Liu, Jianjun
Chew, Fook Tim
author_facet Andiappan, Anand Kumar
Wang, De Yun
Anantharaman, Ramani
Parate, Pallavi Nilkanth
Suri, Bani Kaur
Low, Hui Qi
Li, Yi
Zhao, Wanting
Castagnoli, Paola
Liu, Jianjun
Chew, Fook Tim
author_sort Andiappan, Anand Kumar
collection PubMed
description Allergic rhinitis (AR) is an atopic disease which affects about 600 million people worldwide and results from a complex interplay between genetic and environmental factors. However genetic association studies on known candidate genes yielded variable results. The aim of this study is to identify the genetic variants that influence predisposition towards allergic rhinitis in an ethnic Chinese population in Singapore using a genome-wide association study (GWAS) approach. A total of 4461 ethnic Chinese volunteers were recruited in Singapore and classified according to their allergic disease status. The GWAS included a discovery stage comparing 515 atopic cases (including 456 AR cases) and 486 non-allergic non-rhinitis (NANR) controls. The top SNPs were then validated in a replication cohort consisting of a separate 2323 atopic cases (including 676 AR cases) and 511 NANR controls. Two SNPs showed consistent association in both discovery and replication phases; MRPL4 SNP rs8111930 on 19q13.2 (OR = 0.69, P(combined) = 4.46×10(−05)) and BCAP SNP rs505010 on chromosome 10q24.1 (OR = 0.64, P(combined) = 1.10×10(−04)). In addition, we also replicated multiple associations within known candidates regions such as HLA-DQ and NPSR1 locus in the discovery phase. Our study suggests that MRPL4 and BCAP, key components of the HIF-1α and PI3K/Akt signaling pathways respectively, are two novel candidate genes for atopy and allergic rhinitis. Further study on these molecules and their signaling pathways would help in understanding of the pathogenesis of allergic rhinitis and identification of targets for new therapeutic intervention.
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spelling pubmed-30988462011-05-27 Genome-Wide Association Study for Atopy and Allergic Rhinitis in a Singapore Chinese Population Andiappan, Anand Kumar Wang, De Yun Anantharaman, Ramani Parate, Pallavi Nilkanth Suri, Bani Kaur Low, Hui Qi Li, Yi Zhao, Wanting Castagnoli, Paola Liu, Jianjun Chew, Fook Tim PLoS One Research Article Allergic rhinitis (AR) is an atopic disease which affects about 600 million people worldwide and results from a complex interplay between genetic and environmental factors. However genetic association studies on known candidate genes yielded variable results. The aim of this study is to identify the genetic variants that influence predisposition towards allergic rhinitis in an ethnic Chinese population in Singapore using a genome-wide association study (GWAS) approach. A total of 4461 ethnic Chinese volunteers were recruited in Singapore and classified according to their allergic disease status. The GWAS included a discovery stage comparing 515 atopic cases (including 456 AR cases) and 486 non-allergic non-rhinitis (NANR) controls. The top SNPs were then validated in a replication cohort consisting of a separate 2323 atopic cases (including 676 AR cases) and 511 NANR controls. Two SNPs showed consistent association in both discovery and replication phases; MRPL4 SNP rs8111930 on 19q13.2 (OR = 0.69, P(combined) = 4.46×10(−05)) and BCAP SNP rs505010 on chromosome 10q24.1 (OR = 0.64, P(combined) = 1.10×10(−04)). In addition, we also replicated multiple associations within known candidates regions such as HLA-DQ and NPSR1 locus in the discovery phase. Our study suggests that MRPL4 and BCAP, key components of the HIF-1α and PI3K/Akt signaling pathways respectively, are two novel candidate genes for atopy and allergic rhinitis. Further study on these molecules and their signaling pathways would help in understanding of the pathogenesis of allergic rhinitis and identification of targets for new therapeutic intervention. Public Library of Science 2011-05-20 /pmc/articles/PMC3098846/ /pubmed/21625490 http://dx.doi.org/10.1371/journal.pone.0019719 Text en Andiappan et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Andiappan, Anand Kumar
Wang, De Yun
Anantharaman, Ramani
Parate, Pallavi Nilkanth
Suri, Bani Kaur
Low, Hui Qi
Li, Yi
Zhao, Wanting
Castagnoli, Paola
Liu, Jianjun
Chew, Fook Tim
Genome-Wide Association Study for Atopy and Allergic Rhinitis in a Singapore Chinese Population
title Genome-Wide Association Study for Atopy and Allergic Rhinitis in a Singapore Chinese Population
title_full Genome-Wide Association Study for Atopy and Allergic Rhinitis in a Singapore Chinese Population
title_fullStr Genome-Wide Association Study for Atopy and Allergic Rhinitis in a Singapore Chinese Population
title_full_unstemmed Genome-Wide Association Study for Atopy and Allergic Rhinitis in a Singapore Chinese Population
title_short Genome-Wide Association Study for Atopy and Allergic Rhinitis in a Singapore Chinese Population
title_sort genome-wide association study for atopy and allergic rhinitis in a singapore chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098846/
https://www.ncbi.nlm.nih.gov/pubmed/21625490
http://dx.doi.org/10.1371/journal.pone.0019719
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