Molecular Design, Functional Characterization and Structural Basis of a Protein Inhibitor Against the HIV-1 Pathogenicity Factor Nef

Increased spread of HIV-1 and rapid emergence of drug resistance warrants development of novel antiviral strategies. Nef, a critical viral pathogenicity factor that interacts with host cell factors but lacks enzymatic activity, is not targeted by current antiviral measures. Here we inhibit Nef funct...

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Detalles Bibliográficos
Autores principales: Breuer, Sebastian, Schievink, Simone I., Schulte, Antje, Blankenfeldt, Wulf, Fackler, Oliver T., Geyer, Matthias
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098852/
https://www.ncbi.nlm.nih.gov/pubmed/21625496
http://dx.doi.org/10.1371/journal.pone.0020033

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