Aspartoacylase-LacZ Knockin Mice: An Engineered Model of Canavan Disease

Canavan Disease (CD) is a recessive leukodystrophy caused by loss of function mutations in the gene encoding aspartoacylase (ASPA), an oligodendrocyte-enriched enzyme that hydrolyses N-acetylaspartate (NAA) to acetate and aspartate. The neurological phenotypes of different rodent models of CD vary c...

Descripción completa

Detalles Bibliográficos
Autores principales: Mersmann, Nadine, Tkachev, Dmitri, Jelinek, Ruth, Röth, Philipp Thomas, Möbius, Wiebke, Ruhwedel, Torben, Rühle, Sabine, Weber-Fahr, Wolfgang, Sartorius, Alexander, Klugmann, Matthias
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098885/
https://www.ncbi.nlm.nih.gov/pubmed/21625469
http://dx.doi.org/10.1371/journal.pone.0020336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098885/
https://www.ncbi.nlm.nih.gov/pubmed/21625469
http://dx.doi.org/10.1371/journal.pone.0020336

Ejemplares similares