In Vitro and Ex Vivo Evaluation of Smart Infra-Red Fluorescent Caspase-3 Probes for Molecular Imaging of Cardiovascular Apoptosis

Purpose. The aim of this paper is to develop new optical bioprobes for the imaging of apoptosis. Procedure. We developed quenched near-infrared probes which become fluorescent upon cleavage by caspase-3, the key regulatory enzyme of apoptosis. Results. Probes were shown to be selectively cleaved by...

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Detalles Bibliográficos
Autores principales: Debunne, Manuelle, Portal, Christophe, Delest, Bruno, Brakenhielm, Ebba, Lallemand, Françoise, Henry, Jean-Paul, Ligeret, Heidi, Noack, Pauline, Massonneau, Marc, Romieu, Anthony, Renard, Pierre-Yves, Thuillez, Christian, Richard, Vincent
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099191/
https://www.ncbi.nlm.nih.gov/pubmed/21629849
http://dx.doi.org/10.1155/2011/413290

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