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Vascular Endothelial Growth Factor Inhibitor-Induced Hypertension: Basics for Primary Care Providers
Frequently, primary care providers continue to manage the overall medical care of cancer patients. With newer and often more potent antitumor agents, patients may present to their local physicians with drug-induced toxicities such as hypertension induced by vascular endothelial growth factor (VEGF)...
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Formato: | Texto |
Lenguaje: | English |
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SAGE-Hindawi Access to Research
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099203/ https://www.ncbi.nlm.nih.gov/pubmed/21629798 http://dx.doi.org/10.4061/2011/816897 |
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author | Escalante, Carmen P. Zalpour, Ali |
author_facet | Escalante, Carmen P. Zalpour, Ali |
author_sort | Escalante, Carmen P. |
collection | PubMed |
description | Frequently, primary care providers continue to manage the overall medical care of cancer patients. With newer and often more potent antitumor agents, patients may present to their local physicians with drug-induced toxicities such as hypertension induced by vascular endothelial growth factor (VEGF) inhibitors. It is imperative that these healthcare providers are aware of basic aspects of this drug class, as its use has increased significantly in the last several years. Uncontrolled or malignant hypertension due to these agents should be recognized readily and treated early to prevent more severe outcomes. This overview provides a brief background on the role of VEGF and angiogenesis in tumor metabolism as well as theories of the mechanism of VEGF inhibitors and hypertension. Helpful clinical practice aspects including the types of inhibitors used in the United States and their pharmacologic characteristics will be discussed. Also, diagnosis and treatment of hypertension induced by vascular endothelial growth factors are reviewed. A summary of key aspects of this drug class and hypertension is included. |
format | Text |
id | pubmed-3099203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-30992032011-05-31 Vascular Endothelial Growth Factor Inhibitor-Induced Hypertension: Basics for Primary Care Providers Escalante, Carmen P. Zalpour, Ali Cardiol Res Pract Review Article Frequently, primary care providers continue to manage the overall medical care of cancer patients. With newer and often more potent antitumor agents, patients may present to their local physicians with drug-induced toxicities such as hypertension induced by vascular endothelial growth factor (VEGF) inhibitors. It is imperative that these healthcare providers are aware of basic aspects of this drug class, as its use has increased significantly in the last several years. Uncontrolled or malignant hypertension due to these agents should be recognized readily and treated early to prevent more severe outcomes. This overview provides a brief background on the role of VEGF and angiogenesis in tumor metabolism as well as theories of the mechanism of VEGF inhibitors and hypertension. Helpful clinical practice aspects including the types of inhibitors used in the United States and their pharmacologic characteristics will be discussed. Also, diagnosis and treatment of hypertension induced by vascular endothelial growth factors are reviewed. A summary of key aspects of this drug class and hypertension is included. SAGE-Hindawi Access to Research 2011-05-10 /pmc/articles/PMC3099203/ /pubmed/21629798 http://dx.doi.org/10.4061/2011/816897 Text en Copyright © 2011 C. P. Escalante and A. Zalpour. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Escalante, Carmen P. Zalpour, Ali Vascular Endothelial Growth Factor Inhibitor-Induced Hypertension: Basics for Primary Care Providers |
title | Vascular Endothelial Growth Factor Inhibitor-Induced Hypertension: Basics for Primary Care Providers |
title_full | Vascular Endothelial Growth Factor Inhibitor-Induced Hypertension: Basics for Primary Care Providers |
title_fullStr | Vascular Endothelial Growth Factor Inhibitor-Induced Hypertension: Basics for Primary Care Providers |
title_full_unstemmed | Vascular Endothelial Growth Factor Inhibitor-Induced Hypertension: Basics for Primary Care Providers |
title_short | Vascular Endothelial Growth Factor Inhibitor-Induced Hypertension: Basics for Primary Care Providers |
title_sort | vascular endothelial growth factor inhibitor-induced hypertension: basics for primary care providers |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099203/ https://www.ncbi.nlm.nih.gov/pubmed/21629798 http://dx.doi.org/10.4061/2011/816897 |
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