2-[6,8-Dibromo-3-(4-hy­droxy­cyclo­hex­yl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]phenol methanol 0.25-solvate

The title compound, C(20)H(22)Br(2)N(2)O(2)·0.25CH(4)O, was synthesized by the condensation reaction of salicyl­aldehyde with 4-(2-amino-3,5-dibromo­benzyl­amino)­cyclo­hexa­nol in methanol. There are four independent main mol­ecules and two half-occupied methanol solvent mol­ecules in the asymmetri...

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Detalles Bibliográficos
Autores principales: Wang, Zhi-Gang, Wang, Rong, Zhi, Feng, Wang, Ming-Li
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099869/
https://www.ncbi.nlm.nih.gov/pubmed/21754095
http://dx.doi.org/10.1107/S1600536811007987
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author Wang, Zhi-Gang
Wang, Rong
Zhi, Feng
Wang, Ming-Li
author_facet Wang, Zhi-Gang
Wang, Rong
Zhi, Feng
Wang, Ming-Li
author_sort Wang, Zhi-Gang
collection PubMed
description The title compound, C(20)H(22)Br(2)N(2)O(2)·0.25CH(4)O, was synthesized by the condensation reaction of salicyl­aldehyde with 4-(2-amino-3,5-dibromo­benzyl­amino)­cyclo­hexa­nol in methanol. There are four independent main mol­ecules and two half-occupied methanol solvent mol­ecules in the asymmetric unit. The dihedral angles between the two benzene rings in the four mol­ecules are 87.8 (6), 86.6 (6), 89.3 (6) and 83.1 (6)°. Each mol­ecule features an intra­molecular O—H⋯N hydrogen bond and a short N—H⋯Br link. In the crystal components are linked by O—H⋯O hydrogen bonds.
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spelling pubmed-30998692011-07-13 2-[6,8-Dibromo-3-(4-hy­droxy­cyclo­hex­yl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]phenol methanol 0.25-solvate Wang, Zhi-Gang Wang, Rong Zhi, Feng Wang, Ming-Li Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(20)H(22)Br(2)N(2)O(2)·0.25CH(4)O, was synthesized by the condensation reaction of salicyl­aldehyde with 4-(2-amino-3,5-dibromo­benzyl­amino)­cyclo­hexa­nol in methanol. There are four independent main mol­ecules and two half-occupied methanol solvent mol­ecules in the asymmetric unit. The dihedral angles between the two benzene rings in the four mol­ecules are 87.8 (6), 86.6 (6), 89.3 (6) and 83.1 (6)°. Each mol­ecule features an intra­molecular O—H⋯N hydrogen bond and a short N—H⋯Br link. In the crystal components are linked by O—H⋯O hydrogen bonds. International Union of Crystallography 2011-03-09 /pmc/articles/PMC3099869/ /pubmed/21754095 http://dx.doi.org/10.1107/S1600536811007987 Text en © Wang et al. 2011 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Wang, Zhi-Gang
Wang, Rong
Zhi, Feng
Wang, Ming-Li
2-[6,8-Dibromo-3-(4-hy­droxy­cyclo­hex­yl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]phenol methanol 0.25-solvate
title 2-[6,8-Dibromo-3-(4-hy­droxy­cyclo­hex­yl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]phenol methanol 0.25-solvate
title_full 2-[6,8-Dibromo-3-(4-hy­droxy­cyclo­hex­yl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]phenol methanol 0.25-solvate
title_fullStr 2-[6,8-Dibromo-3-(4-hy­droxy­cyclo­hex­yl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]phenol methanol 0.25-solvate
title_full_unstemmed 2-[6,8-Dibromo-3-(4-hy­droxy­cyclo­hex­yl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]phenol methanol 0.25-solvate
title_short 2-[6,8-Dibromo-3-(4-hy­droxy­cyclo­hex­yl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]phenol methanol 0.25-solvate
title_sort 2-[6,8-dibromo-3-(4-hy­droxy­cyclo­hex­yl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]phenol methanol 0.25-solvate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099869/
https://www.ncbi.nlm.nih.gov/pubmed/21754095
http://dx.doi.org/10.1107/S1600536811007987
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