4,5-Bis(4-fluoro­phen­yl)-5-hy­droxy-3-(2-methyl­propano­yl)-1-phenyl­pyrrolidin-2-one

The title compound, C(26)H(23)F(2)NO(3), was synthesized by the reaction of 2-(4-fluoro­benzyl­idene)-4-methyl-3-oxo-N-phenyl­penta­namide and 4-fluoro­benzaldehyde. The dihedral angles between the mean plane through the pyrrolidine ring (nearly planar; maximum deviation of 0.145 Å for the C atom be...

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Detalles Bibliográficos
Autores principales: Huang, Jian-Ying, Zhou, Fengyan
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099992/
https://www.ncbi.nlm.nih.gov/pubmed/21754151
http://dx.doi.org/10.1107/S1600536811008786
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author Huang, Jian-Ying
Zhou, Fengyan
author_facet Huang, Jian-Ying
Zhou, Fengyan
author_sort Huang, Jian-Ying
collection PubMed
description The title compound, C(26)H(23)F(2)NO(3), was synthesized by the reaction of 2-(4-fluoro­benzyl­idene)-4-methyl-3-oxo-N-phenyl­penta­namide and 4-fluoro­benzaldehyde. The dihedral angles between the mean plane through the pyrrolidine ring (nearly planar; maximum deviation of 0.145 Å for the C atom bearing the hydroxy group) with the phenyl and benzene rings are 37.22 (7), 51.88 (7) and 87.64 (9)°, respectively. The pyyolidine ring is near coplaner, with max offset of 0.145 A for C19 atom.\uff09 In the crystal, mol­ecules are linked by pairs of O—H⋯O hydrogen bonds into inversion dimers, which are further assembled into chains parallel to the b axis by weak C—H⋯O hydrogen bonds.
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spelling pubmed-30999922011-07-13 4,5-Bis(4-fluoro­phen­yl)-5-hy­droxy-3-(2-methyl­propano­yl)-1-phenyl­pyrrolidin-2-one Huang, Jian-Ying Zhou, Fengyan Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(26)H(23)F(2)NO(3), was synthesized by the reaction of 2-(4-fluoro­benzyl­idene)-4-methyl-3-oxo-N-phenyl­penta­namide and 4-fluoro­benzaldehyde. The dihedral angles between the mean plane through the pyrrolidine ring (nearly planar; maximum deviation of 0.145 Å for the C atom bearing the hydroxy group) with the phenyl and benzene rings are 37.22 (7), 51.88 (7) and 87.64 (9)°, respectively. The pyyolidine ring is near coplaner, with max offset of 0.145 A for C19 atom.\uff09 In the crystal, mol­ecules are linked by pairs of O—H⋯O hydrogen bonds into inversion dimers, which are further assembled into chains parallel to the b axis by weak C—H⋯O hydrogen bonds. International Union of Crystallography 2011-03-12 /pmc/articles/PMC3099992/ /pubmed/21754151 http://dx.doi.org/10.1107/S1600536811008786 Text en © Huang and Zhou 2011 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Huang, Jian-Ying
Zhou, Fengyan
4,5-Bis(4-fluoro­phen­yl)-5-hy­droxy-3-(2-methyl­propano­yl)-1-phenyl­pyrrolidin-2-one
title 4,5-Bis(4-fluoro­phen­yl)-5-hy­droxy-3-(2-methyl­propano­yl)-1-phenyl­pyrrolidin-2-one
title_full 4,5-Bis(4-fluoro­phen­yl)-5-hy­droxy-3-(2-methyl­propano­yl)-1-phenyl­pyrrolidin-2-one
title_fullStr 4,5-Bis(4-fluoro­phen­yl)-5-hy­droxy-3-(2-methyl­propano­yl)-1-phenyl­pyrrolidin-2-one
title_full_unstemmed 4,5-Bis(4-fluoro­phen­yl)-5-hy­droxy-3-(2-methyl­propano­yl)-1-phenyl­pyrrolidin-2-one
title_short 4,5-Bis(4-fluoro­phen­yl)-5-hy­droxy-3-(2-methyl­propano­yl)-1-phenyl­pyrrolidin-2-one
title_sort 4,5-bis(4-fluoro­phen­yl)-5-hy­droxy-3-(2-methyl­propano­yl)-1-phenyl­pyrrolidin-2-one
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099992/
https://www.ncbi.nlm.nih.gov/pubmed/21754151
http://dx.doi.org/10.1107/S1600536811008786
work_keys_str_mv AT huangjianying 45bis4fluorophenyl5hydroxy32methylpropanoyl1phenylpyrrolidin2one
AT zhoufengyan 45bis4fluorophenyl5hydroxy32methylpropanoyl1phenylpyrrolidin2one

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