4-(3-Fluoro­phen­yl)-6-hy­droxy-5-(thio­phen-2-ylcarbon­yl)-6-trifluoro­methyl-1,3-diazinan-2-one

In the title compound, C(16)H(12)F(4)N(2)O(3)S, the pyrimidine ring adopts a half-chair conformation; the mean plane formed by the ring atoms excluding the C atom bonded to the thio­phen-2-ylcarbonyl group has an r.m.s. deviation of 0.059 Å. The dihedral angle between the benzene and thio­phene ring...

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Detalles Bibliográficos
Autores principales: He, Qin, Li, Jing, Huang, Bao-Jun
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100023/
https://www.ncbi.nlm.nih.gov/pubmed/21754056
http://dx.doi.org/10.1107/S1600536811006933
Descripción
Sumario:In the title compound, C(16)H(12)F(4)N(2)O(3)S, the pyrimidine ring adopts a half-chair conformation; the mean plane formed by the ring atoms excluding the C atom bonded to the thio­phen-2-ylcarbonyl group has an r.m.s. deviation of 0.059 Å. The dihedral angle between the benzene and thio­phene rings is 62.26 (7)°. The mol­ecular conformation is stabilized by an intra­molecular O—H⋯O hydrogen bond, generating an S(6) ring. In the crystal, adjacent mol­ecules are connected via a centrosymmetric R (2) (2)(6) motif, formed by N—H⋯O hydrogen bonds.

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