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Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

BACKGROUND: Exosomes or secreted bi-lipid vesicles from human ESC-derived mesenchymal stem cells (hESC-MSCs) have been shown to reduce myocardial ischemia/reperfusion injury in animal models. However, as hESC-MSCs are not infinitely expansible, large scale production of these exosomes would require...

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Detalles Bibliográficos
Autores principales:	Chen, Tian Sheng, Arslan, Fatih, Yin, Yijun, Tan, Soon Sim, Lai, Ruenn Chai, Choo, Andre Boon Hwa, Padmanabhan, Jayanthi, Lee, Chuen Neng, de Kleijn, Dominique PV, Lim, Sai Kiang
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100248/ https://www.ncbi.nlm.nih.gov/pubmed/21513579 http://dx.doi.org/10.1186/1479-5876-9-47

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