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A theoretical entropy score as a single value to express inhibitor selectivity
BACKGROUND: Designing maximally selective ligands that act on individual targets is the dominant paradigm in drug discovery. Poor selectivity can underlie toxicity and side effects in the clinic, and for this reason compound selectivity is increasingly monitored from very early on in the drug discov...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100252/ https://www.ncbi.nlm.nih.gov/pubmed/21486481 http://dx.doi.org/10.1186/1471-2105-12-94 |