Parkin Mediates Apparent E2-Independent Monoubiquitination In Vitro and Contains an Intrinsic Activity That Catalyzes Polyubiquitination

BACKGROUND: Mutations in the parkin gene, which encodes a ubiquitin ligase (E3), are a major cause of autosomal recessive parkinsonism. Although parkin-mediated ubiquitination was initially linked to protein degradation, accumulating evidence suggests that the enzyme is capable of catalyzing multipl...

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Detalles Bibliográficos
Autores principales: Chew, Katherine C. M., Matsuda, Noriyuki, Saisho, Keiko, Lim, Grace G. Y., Chai, Chou, Tan, Hui-Mei, Tanaka, Keiji, Lim, Kah-Leong
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100294/
https://www.ncbi.nlm.nih.gov/pubmed/21625422
http://dx.doi.org/10.1371/journal.pone.0019720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100294/
https://www.ncbi.nlm.nih.gov/pubmed/21625422
http://dx.doi.org/10.1371/journal.pone.0019720

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