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Acute Myeloid Leukemia with the t(8;21) Translocation: Clinical Consequences and Biological Implications
The t(8;21) abnormality occurs in a minority of acute myeloid leukemia (AML) patients. The translocation results in an in-frame fusion of two genes, resulting in a fusion protein of one N-terminal domain from the AML1 gene and four C-terminal domains from the ETO gene. This protein has multiple effe...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100545/ https://www.ncbi.nlm.nih.gov/pubmed/21629739 http://dx.doi.org/10.1155/2011/104631 |