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Mitochondria and PGC-1α in Aging and Age-Associated Diseases
Aging is the most significant risk factor for a range of degenerative disease such as cardiovascular, neurodegenerative and metabolic disorders. While the cause of aging and its associated diseases is multifactorial, mitochondrial dysfunction has been implicated in the aging process and the onset an...
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Formato: | Texto |
Lenguaje: | English |
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SAGE-Hindawi Access to Research
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100651/ https://www.ncbi.nlm.nih.gov/pubmed/21629705 http://dx.doi.org/10.4061/2011/810619 |
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author | Wenz, Tina |
author_facet | Wenz, Tina |
author_sort | Wenz, Tina |
collection | PubMed |
description | Aging is the most significant risk factor for a range of degenerative disease such as cardiovascular, neurodegenerative and metabolic disorders. While the cause of aging and its associated diseases is multifactorial, mitochondrial dysfunction has been implicated in the aging process and the onset and progression of age-associated disorders. Recent studies indicate that maintenance of mitochondrial function is beneficial in the prevention or delay of age-associated diseases. A central molecule seems to be the peroxisome proliferator-activated receptor γ coactivator α (PGC-1α), which is the key regulator of mitochondrial biogenesis. Besides regulating mitochondrial function, PGC-1α targets several other cellular processes and thereby influences cell fate on multiple levels. This paper discusses how mitochondrial function and PGC-1α are affected in age-associated diseases and how modulation of PGC-1α might offer a therapeutic potential for age-related pathology. |
format | Text |
id | pubmed-3100651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-31006512011-05-31 Mitochondria and PGC-1α in Aging and Age-Associated Diseases Wenz, Tina J Aging Res Review Article Aging is the most significant risk factor for a range of degenerative disease such as cardiovascular, neurodegenerative and metabolic disorders. While the cause of aging and its associated diseases is multifactorial, mitochondrial dysfunction has been implicated in the aging process and the onset and progression of age-associated disorders. Recent studies indicate that maintenance of mitochondrial function is beneficial in the prevention or delay of age-associated diseases. A central molecule seems to be the peroxisome proliferator-activated receptor γ coactivator α (PGC-1α), which is the key regulator of mitochondrial biogenesis. Besides regulating mitochondrial function, PGC-1α targets several other cellular processes and thereby influences cell fate on multiple levels. This paper discusses how mitochondrial function and PGC-1α are affected in age-associated diseases and how modulation of PGC-1α might offer a therapeutic potential for age-related pathology. SAGE-Hindawi Access to Research 2011-05-05 /pmc/articles/PMC3100651/ /pubmed/21629705 http://dx.doi.org/10.4061/2011/810619 Text en Copyright © 2011 Tina Wenz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wenz, Tina Mitochondria and PGC-1α in Aging and Age-Associated Diseases |
title | Mitochondria and PGC-1α in Aging and Age-Associated Diseases |
title_full | Mitochondria and PGC-1α in Aging and Age-Associated Diseases |
title_fullStr | Mitochondria and PGC-1α in Aging and Age-Associated Diseases |
title_full_unstemmed | Mitochondria and PGC-1α in Aging and Age-Associated Diseases |
title_short | Mitochondria and PGC-1α in Aging and Age-Associated Diseases |
title_sort | mitochondria and pgc-1α in aging and age-associated diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100651/ https://www.ncbi.nlm.nih.gov/pubmed/21629705 http://dx.doi.org/10.4061/2011/810619 |
work_keys_str_mv | AT wenztina mitochondriaandpgc1ainagingandageassociateddiseases |