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Mitochondria and PGC-1α in Aging and Age-Associated Diseases

Aging is the most significant risk factor for a range of degenerative disease such as cardiovascular, neurodegenerative and metabolic disorders. While the cause of aging and its associated diseases is multifactorial, mitochondrial dysfunction has been implicated in the aging process and the onset an...

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Detalles Bibliográficos
Autor principal: Wenz, Tina
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100651/
https://www.ncbi.nlm.nih.gov/pubmed/21629705
http://dx.doi.org/10.4061/2011/810619
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author Wenz, Tina
author_facet Wenz, Tina
author_sort Wenz, Tina
collection PubMed
description Aging is the most significant risk factor for a range of degenerative disease such as cardiovascular, neurodegenerative and metabolic disorders. While the cause of aging and its associated diseases is multifactorial, mitochondrial dysfunction has been implicated in the aging process and the onset and progression of age-associated disorders. Recent studies indicate that maintenance of mitochondrial function is beneficial in the prevention or delay of age-associated diseases. A central molecule seems to be the peroxisome proliferator-activated receptor γ coactivator α (PGC-1α), which is the key regulator of mitochondrial biogenesis. Besides regulating mitochondrial function, PGC-1α targets several other cellular processes and thereby influences cell fate on multiple levels. This paper discusses how mitochondrial function and PGC-1α are affected in age-associated diseases and how modulation of PGC-1α might offer a therapeutic potential for age-related pathology.
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spelling pubmed-31006512011-05-31 Mitochondria and PGC-1α in Aging and Age-Associated Diseases Wenz, Tina J Aging Res Review Article Aging is the most significant risk factor for a range of degenerative disease such as cardiovascular, neurodegenerative and metabolic disorders. While the cause of aging and its associated diseases is multifactorial, mitochondrial dysfunction has been implicated in the aging process and the onset and progression of age-associated disorders. Recent studies indicate that maintenance of mitochondrial function is beneficial in the prevention or delay of age-associated diseases. A central molecule seems to be the peroxisome proliferator-activated receptor γ coactivator α (PGC-1α), which is the key regulator of mitochondrial biogenesis. Besides regulating mitochondrial function, PGC-1α targets several other cellular processes and thereby influences cell fate on multiple levels. This paper discusses how mitochondrial function and PGC-1α are affected in age-associated diseases and how modulation of PGC-1α might offer a therapeutic potential for age-related pathology. SAGE-Hindawi Access to Research 2011-05-05 /pmc/articles/PMC3100651/ /pubmed/21629705 http://dx.doi.org/10.4061/2011/810619 Text en Copyright © 2011 Tina Wenz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wenz, Tina
Mitochondria and PGC-1α in Aging and Age-Associated Diseases
title Mitochondria and PGC-1α in Aging and Age-Associated Diseases
title_full Mitochondria and PGC-1α in Aging and Age-Associated Diseases
title_fullStr Mitochondria and PGC-1α in Aging and Age-Associated Diseases
title_full_unstemmed Mitochondria and PGC-1α in Aging and Age-Associated Diseases
title_short Mitochondria and PGC-1α in Aging and Age-Associated Diseases
title_sort mitochondria and pgc-1α in aging and age-associated diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100651/
https://www.ncbi.nlm.nih.gov/pubmed/21629705
http://dx.doi.org/10.4061/2011/810619
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