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Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics

BACKGROUND: Acute myeloid leukemia (AML) is a life-threatening malignancy with limited treatment options in chemotherapy-refractory patients. A first-in-human dose study was designed to investigate a safe and biologically effective dose range for LY2457546, a novel multikinase inhibitor, in patients...

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Detalles Bibliográficos
Autores principales:	Wacheck, Volker, Lahn, Michael, Dickinson, Gemma, Füreder, Wolfgang, Meyer, Renata, Herndlhofer, Susanne, Füreder, Thorsten, Dorfner, Georg, Pillay, Sada, André, Valérie, Burkholder, Timothy P, Akunda, Jacqueline K, Flye-Blakemore, Leann, Van Bockstaele, Dirk, Schlenk, Richard F, Sperr, Wolfgang R, Valent, Peter
Formato:	Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2011
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101112/ https://www.ncbi.nlm.nih.gov/pubmed/21625399 http://dx.doi.org/10.2147/CMR.S19341

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