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Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation

BACKGROUND: The essential purine salvage pathway of Trypanosoma brucei bears interesting catalytic enzymes for chemotherapeutic intervention of Human African Trypanosomiasis. Unlike mammalian cells, trypanosomes lack de novo purine synthesis and completely rely on salvage from their hosts. One of th...

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Detalles Bibliográficos
Autores principales: Kuettel, Sabine, Greenwald, Jason, Kostrewa, Dirk, Ahmed, Shaheen, Scapozza, Leonardo, Perozzo, Remo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101181/
https://www.ncbi.nlm.nih.gov/pubmed/21629723
http://dx.doi.org/10.1371/journal.pntd.0001164