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Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy

OBJECTIVE: We undertook this study to assess the agreement between fetal umbilical cord drug levels and maternal self-report. STUDY DESIGN: Cord samples were collected from 103 placentas after delivery as a sub-project of the larger Pacific Research Center for Early Human Development (PRCEHD) study....

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Autores principales: Wright, Tricia E, Milam, Kristen A, Rougee, Luc, Tanaka, Marissa D, Collier, Abby C
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101267/
https://www.ncbi.nlm.nih.gov/pubmed/21151006
http://dx.doi.org/10.1038/jp.2010.132
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author Wright, Tricia E
Milam, Kristen A
Rougee, Luc
Tanaka, Marissa D
Collier, Abby C
author_facet Wright, Tricia E
Milam, Kristen A
Rougee, Luc
Tanaka, Marissa D
Collier, Abby C
author_sort Wright, Tricia E
collection PubMed
description OBJECTIVE: We undertook this study to assess the agreement between fetal umbilical cord drug levels and maternal self-report. STUDY DESIGN: Cord samples were collected from 103 placentas after delivery as a sub-project of the larger Pacific Research Center for Early Human Development (PRCEHD) study. These cord samples were then processed to obtain cord lysates and enzyme-linked immunosorbent assay (ELISA) performed for cotinine and illicit drugs. Levels of each of these substances were compared with clinical information. RESULTS: We found fair agreement between self-reported smoking and cotinine levels (kappa = 0.26 (0.07–0.5)) as well as slight agreement with current drug use and positive drug levels (kappa = 0.19 (−0.05–0.4)). Compared with maternal self-report, sensitivity of cotinine levels was 27% and specificity was 98%. Sensitivity of positive cord illicit drug levels was 32% and specificity was 85%. CONCLUSION: Umbilical cords provide another independent measure of maternal drug use and are readily available. To our knowledge, this is the first study to measure cotinine levels in the umbilical cord tissue.
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spelling pubmed-31012672011-11-01 Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy Wright, Tricia E Milam, Kristen A Rougee, Luc Tanaka, Marissa D Collier, Abby C J Perinatol Article OBJECTIVE: We undertook this study to assess the agreement between fetal umbilical cord drug levels and maternal self-report. STUDY DESIGN: Cord samples were collected from 103 placentas after delivery as a sub-project of the larger Pacific Research Center for Early Human Development (PRCEHD) study. These cord samples were then processed to obtain cord lysates and enzyme-linked immunosorbent assay (ELISA) performed for cotinine and illicit drugs. Levels of each of these substances were compared with clinical information. RESULTS: We found fair agreement between self-reported smoking and cotinine levels (kappa = 0.26 (0.07–0.5)) as well as slight agreement with current drug use and positive drug levels (kappa = 0.19 (−0.05–0.4)). Compared with maternal self-report, sensitivity of cotinine levels was 27% and specificity was 98%. Sensitivity of positive cord illicit drug levels was 32% and specificity was 85%. CONCLUSION: Umbilical cords provide another independent measure of maternal drug use and are readily available. To our knowledge, this is the first study to measure cotinine levels in the umbilical cord tissue. 2010-12-09 2011-05 /pmc/articles/PMC3101267/ /pubmed/21151006 http://dx.doi.org/10.1038/jp.2010.132 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Wright, Tricia E
Milam, Kristen A
Rougee, Luc
Tanaka, Marissa D
Collier, Abby C
Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy
title Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy
title_full Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy
title_fullStr Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy
title_full_unstemmed Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy
title_short Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy
title_sort agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101267/
https://www.ncbi.nlm.nih.gov/pubmed/21151006
http://dx.doi.org/10.1038/jp.2010.132
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