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Binding modes of diketo-acid inhibitors of HIV-1 integrase: A comparative molecular dynamics simulation study

HIV-1 integrase (IN) has become an attractive target since drug resistance against HIV-1 reverse transcriptase (RT) and protease (PR) has appeared. Diketo acid (DKA) inhibitors are potent and selective inhibitors of HIV-1 IN: however the action mechanism is not well understood. Here, to study the in...

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Detalles Bibliográficos
Autores principales:	Huang, Meilan, Grant, Guy H., Richards, W. Graham
Formato:	Texto
Lenguaje:	English
Publicado:	Elsevier Science, Inc 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101338/ https://www.ncbi.nlm.nih.gov/pubmed/21531158 http://dx.doi.org/10.1016/j.jmgm.2011.04.002

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