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Predictive factors for new onset or progression of knee osteoarthritis one year after trauma: MRI follow-up in general practice

OBJECTIVE: To prospectively evaluate prognostic factors for new onset or progression of degenerative change on follow-up MRI one year after knee trauma and the association with clinical outcome. METHODS: Within a prospective observational cohort study in general practice, we studied a subgroup of 11...

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Detalles Bibliográficos
Autores principales: Koster, Ingrid M., Oei, Edwin H. G., Hensen, Jan-Hein J., Boks, Simone S., Koes, Bart W., Vroegindeweij, Dammis, Hunink, M. G. Myriam, Bierma-Zeinstra, Sita M. A.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101345/
https://www.ncbi.nlm.nih.gov/pubmed/21380741
http://dx.doi.org/10.1007/s00330-011-2089-3
Descripción
Sumario:OBJECTIVE: To prospectively evaluate prognostic factors for new onset or progression of degenerative change on follow-up MRI one year after knee trauma and the association with clinical outcome. METHODS: Within a prospective observational cohort study in general practice, we studied a subgroup of 117 patients with acute knee trauma (mean age 41 years, 43% women). Degenerative change was scored on MRI at baseline and after one year follow-up. Multivariate logistic regression analysis was performed to evaluate prognostic factors for new onset or progressive degenerative change on follow-up MRI. Association between new or progressive degeneration and clinical outcome after one year was assessed. RESULTS: On follow-up MRI 15% of patients with pre-existing knee osteoarthritis showed progression and 26% of patients demonstrated new degenerative change. The only statistically significant prognostic variable in the multivariate analysis was bone marrow oedema on initial MRI (OR 5.29 (95% CI 1.64–17.1), p = 0.005). A significant association between new or progressive degenerative change and clinical outcome was found (p = 0.003). CONCLUSION: Bone marrow oedema on MRI for acute knee injury is strongly predictive of new onset or progression of degenerative change of the femorotibial joint on follow-up MRI one year after trauma, which is reflected in clinical outcome.