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Diagnostic benefits of presurgical fMRI in patients with brain tumours in the primary sensorimotor cortex

OBJECTIVES: Reliable imaging of eloquent tumour-adjacent brain areas is necessary for planning function-preserving neurosurgery. This study evaluates the potential diagnostic benefits of presurgical functional magnetic resonance imaging (fMRI) in comparison to a detailed analysis of morphological MR...

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Autores principales: Wengenroth, Martina, Blatow, M., Guenther, J., Akbar, M., Tronnier, V. M., Stippich, C.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101350/
https://www.ncbi.nlm.nih.gov/pubmed/21271252
http://dx.doi.org/10.1007/s00330-011-2067-9
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author Wengenroth, Martina
Blatow, M.
Guenther, J.
Akbar, M.
Tronnier, V. M.
Stippich, C.
author_facet Wengenroth, Martina
Blatow, M.
Guenther, J.
Akbar, M.
Tronnier, V. M.
Stippich, C.
author_sort Wengenroth, Martina
collection PubMed
description OBJECTIVES: Reliable imaging of eloquent tumour-adjacent brain areas is necessary for planning function-preserving neurosurgery. This study evaluates the potential diagnostic benefits of presurgical functional magnetic resonance imaging (fMRI) in comparison to a detailed analysis of morphological MRI data. METHODS: Standardised preoperative functional and structural neuroimaging was performed on 77 patients with rolandic mass lesions at 1.5 Tesla. The central region of both hemispheres was allocated using six morphological and three functional landmarks. RESULTS: fMRI enabled localisation of the motor hand area in 76/77 patients, which was significantly superior to analysis of structural MRI (confident localisation of motor hand area in 66/77 patients; p < 0.002). FMRI provided additional diagnostic information in 96% (tongue representation) and 97% (foot representation) of patients. FMRI-based presurgical risk assessment correlated in 88% with a positive postoperative clinical outcome. CONCLUSION: Routine presurgical FMRI allows for superior assessment of the spatial relationship between brain tumour and motor cortex compared with a very detailed analysis of structural 3D MRI, thus significantly facilitating the preoperative risk-benefit assessment and function-preserving surgery. The additional imaging time seems justified. FMRI has the potential to reduce postoperative morbidity and therefore hospitalisation time.
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spelling pubmed-31013502011-07-14 Diagnostic benefits of presurgical fMRI in patients with brain tumours in the primary sensorimotor cortex Wengenroth, Martina Blatow, M. Guenther, J. Akbar, M. Tronnier, V. M. Stippich, C. Eur Radiol Neuro OBJECTIVES: Reliable imaging of eloquent tumour-adjacent brain areas is necessary for planning function-preserving neurosurgery. This study evaluates the potential diagnostic benefits of presurgical functional magnetic resonance imaging (fMRI) in comparison to a detailed analysis of morphological MRI data. METHODS: Standardised preoperative functional and structural neuroimaging was performed on 77 patients with rolandic mass lesions at 1.5 Tesla. The central region of both hemispheres was allocated using six morphological and three functional landmarks. RESULTS: fMRI enabled localisation of the motor hand area in 76/77 patients, which was significantly superior to analysis of structural MRI (confident localisation of motor hand area in 66/77 patients; p < 0.002). FMRI provided additional diagnostic information in 96% (tongue representation) and 97% (foot representation) of patients. FMRI-based presurgical risk assessment correlated in 88% with a positive postoperative clinical outcome. CONCLUSION: Routine presurgical FMRI allows for superior assessment of the spatial relationship between brain tumour and motor cortex compared with a very detailed analysis of structural 3D MRI, thus significantly facilitating the preoperative risk-benefit assessment and function-preserving surgery. The additional imaging time seems justified. FMRI has the potential to reduce postoperative morbidity and therefore hospitalisation time. Springer-Verlag 2011-01-28 2011 /pmc/articles/PMC3101350/ /pubmed/21271252 http://dx.doi.org/10.1007/s00330-011-2067-9 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Neuro
Wengenroth, Martina
Blatow, M.
Guenther, J.
Akbar, M.
Tronnier, V. M.
Stippich, C.
Diagnostic benefits of presurgical fMRI in patients with brain tumours in the primary sensorimotor cortex
title Diagnostic benefits of presurgical fMRI in patients with brain tumours in the primary sensorimotor cortex
title_full Diagnostic benefits of presurgical fMRI in patients with brain tumours in the primary sensorimotor cortex
title_fullStr Diagnostic benefits of presurgical fMRI in patients with brain tumours in the primary sensorimotor cortex
title_full_unstemmed Diagnostic benefits of presurgical fMRI in patients with brain tumours in the primary sensorimotor cortex
title_short Diagnostic benefits of presurgical fMRI in patients with brain tumours in the primary sensorimotor cortex
title_sort diagnostic benefits of presurgical fmri in patients with brain tumours in the primary sensorimotor cortex
topic Neuro
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101350/
https://www.ncbi.nlm.nih.gov/pubmed/21271252
http://dx.doi.org/10.1007/s00330-011-2067-9
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