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Mammalian Sirtuins and Energy Metabolism

Sirtuins are highly conserved NAD(+)-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerged as key metabolic sensors that directly link en...

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Detalles Bibliográficos
Autores principales: Li, Xiaoling, Kazgan, Nevzat
Formato: Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101526/
https://www.ncbi.nlm.nih.gov/pubmed/21614150
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author Li, Xiaoling
Kazgan, Nevzat
author_facet Li, Xiaoling
Kazgan, Nevzat
author_sort Li, Xiaoling
collection PubMed
description Sirtuins are highly conserved NAD(+)-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerged as key metabolic sensors that directly link environmental signals to mammalian metabolic homeostasis and stress response. Recent studies have shed light on the critical roles of sirtuins in mammalian energy metabolism in response to nutrient signals. This review focuses on the involvement of two nuclear sirtuins, SIRT1 and SIRT6, and three mitochondrial sirtuins, SIRT3, SIRT4, and SIRT5, in regulation of diverse metabolic processes.
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spelling pubmed-31015262011-05-25 Mammalian Sirtuins and Energy Metabolism Li, Xiaoling Kazgan, Nevzat Int J Biol Sci Review Sirtuins are highly conserved NAD(+)-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerged as key metabolic sensors that directly link environmental signals to mammalian metabolic homeostasis and stress response. Recent studies have shed light on the critical roles of sirtuins in mammalian energy metabolism in response to nutrient signals. This review focuses on the involvement of two nuclear sirtuins, SIRT1 and SIRT6, and three mitochondrial sirtuins, SIRT3, SIRT4, and SIRT5, in regulation of diverse metabolic processes. Ivyspring International Publisher 2011-05-09 /pmc/articles/PMC3101526/ /pubmed/21614150 Text en © The Author. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Review
Li, Xiaoling
Kazgan, Nevzat
Mammalian Sirtuins and Energy Metabolism
title Mammalian Sirtuins and Energy Metabolism
title_full Mammalian Sirtuins and Energy Metabolism
title_fullStr Mammalian Sirtuins and Energy Metabolism
title_full_unstemmed Mammalian Sirtuins and Energy Metabolism
title_short Mammalian Sirtuins and Energy Metabolism
title_sort mammalian sirtuins and energy metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101526/
https://www.ncbi.nlm.nih.gov/pubmed/21614150
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